Evaluation of wound healing effect of alginate films containing Aloe vera (Aloe barbadensis Miller) gel

被引：35

作者：

Koga, Adriana Y. ^{[1
]}

Pereira, Airton V. ^{[1
]}

Lipinski, Leandro C. ^{[2
]}

Oliveira, Marcia R. P. ^{[3
]}

机构：

[1] Univ Estadual Ponta Grossa, Dept Pharmaceut Sci, Ponta Grossa, Parana, Brazil

[2] Univ Estadual Ponta Grossa, Dept Med, Ponta Grossa, Parana, Brazil

[3] Univ Estadual Ponta Grossa, Dept Struct Mol & Genet Biol, Ponta Grossa, Parana, Brazil

来源：

JOURNAL OF BIOMATERIALS APPLICATIONS | 2018年 / 32卷 / 09期

关键词：

Alginate; film; Aloe vera; dressing; healing; SCAR FORMATION; ANGIOGENESIS; ACTIVATION; ACEMANNAN; HYDROGEL; PROTEIN;

D O I：

10.1177/0885328218754615

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A new alginate dressing with Aloe vera gel was developed and used to study its cutaneous healing effect in vivo by surgical wounds in Wistar rats. The aloe-alginate film was characterized by Fourier-transform infrared spectroscopy, mechanical properties, scanning electron microscopy, hydration rate, and calcium release. The aloe-alginate film demonstrated desirable physical and mechanical characteristics for wound dressing application. The animals were divided in three groups (n=20): gauze bandage, alginate film, and aloe-alginate film. The histological analysis on the 3rd, 7th, 14th, and 22nd days after the treatment showed that the aloe-alginate films modulated the inflammatory phase and decreased the quantity of macrophages when compared to the alginate film group and the control (gauze bandage). The evaluation of collagen fibers showed a decrease in type III and increase in type I fibers on group treated with aloe-alginate film suggesting an improvement in the progression of the healing process.

引用

页码：1212 / 1221

页数：10

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