Evaluation of wound healing effect of alginate films containing Aloe vera (Aloe barbadensis Miller) gel

被引：34
作者：
Koga, Adriana Y. [1 ]
Pereira, Airton V. [1 ]
Lipinski, Leandro C. [2 ]
Oliveira, Marcia R. P. [3 ]
机构：
[1] Univ Estadual Ponta Grossa, Dept Pharmaceut Sci, Ponta Grossa, Parana, Brazil
[2] Univ Estadual Ponta Grossa, Dept Med, Ponta Grossa, Parana, Brazil
[3] Univ Estadual Ponta Grossa, Dept Struct Mol & Genet Biol, Ponta Grossa, Parana, Brazil
来源：
JOURNAL OF BIOMATERIALS APPLICATIONS | 2018年 / 32卷 / 09期
关键词：
Alginate; film; Aloe vera; dressing; healing; SCAR FORMATION; ANGIOGENESIS; ACTIVATION; ACEMANNAN; HYDROGEL; PROTEIN;
D O I：
10.1177/0885328218754615
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A new alginate dressing with Aloe vera gel was developed and used to study its cutaneous healing effect in vivo by surgical wounds in Wistar rats. The aloe-alginate film was characterized by Fourier-transform infrared spectroscopy, mechanical properties, scanning electron microscopy, hydration rate, and calcium release. The aloe-alginate film demonstrated desirable physical and mechanical characteristics for wound dressing application. The animals were divided in three groups (n=20): gauze bandage, alginate film, and aloe-alginate film. The histological analysis on the 3rd, 7th, 14th, and 22nd days after the treatment showed that the aloe-alginate films modulated the inflammatory phase and decreased the quantity of macrophages when compared to the alginate film group and the control (gauze bandage). The evaluation of collagen fibers showed a decrease in type III and increase in type I fibers on group treated with aloe-alginate film suggesting an improvement in the progression of the healing process.
引用
收藏
页码：1212 / 1221
页数：10
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