A Phase 1 First-in-Human Study of Abbv-383, a BCMA x CD3 Bispecific T-Cell-Redirecting Antibody, As Monotherapy in Patients with Relapsed/Refractory Multiple Myeloma

被引：16

作者：

Voorhees, Peter M. ^{[1
]}

D'Souza, Anita ^{[2
]}

Weisel, Katja ^{[3
]}

Hurd, David Duane ^{[4
]}

Teipel, Raphael ^{[5
]}

Chung, Alfred ^{[6
]}

Rodriguez, Cesar ^{[7
]}

Tuchman, Sascha A. ^{[8
]}

Korde, Neha ^{[9
]}

Safah, Hana ^{[10
]}

Bueno, Orlando F. ^{[11
]}

Pumford, Neil ^{[11
]}

Rosenberg, Tanya S. ^{[11
]}

Pothacamury, Rajvineeth Kumar ^{[11
]}

Ross, Jeremy A. ^{[11
]}

Polepally, Akshanth R. ^{[11
]}

Lee, Shane ^{[11
]}

Jin, Ziyi ^{[11
]}

Talati, Chetasi ^{[11
]}

Vij, Ravi ^{[12
]}

Kumar, Shaji K. ^{[13
]}

机构：

[1] Atrium Hlth Wake Forest Baptist, Levine Canc Inst, Dept Hematol Oncol & Blood Disorders, Plasma Cell Disorders Sect, Charlotte, NC USA

[2] Froedtert & Med Coll Wisconsin Canc Ctr, Dept Med, Div Hematol Oncol, Milwaukee, WI USA

[3] Univ Med Ctr Hamburg Eppendorf, Sect Pneumol, Dept Oncol Hematol & Bone Marrow Transplantat, Hamburg, Germany

[4] Wake Forest Univ, Bowman Gray Sch Med, Dept Med, Sect Hematol & Oncol, Winston Salem, NC 27103 USA

[5] Univ Klinikum Dresden, Med Klin 1, Dresden, Germany

[6] Univ Calif San Francisco, Dept Med, Div Hematol Oncol, San Francisco, CA 94143 USA

[7] Wake Forest Univ, Bowman Gray Sch Med, Med Oncol & Hematol, Winston Salem, NC USA

[8] Univ N Carolina, Div Hematol, Chapel Hill, NC 27515 USA

[9] Mem Sloan Kettering Canc Ctr, Dept Med, Myeloma Serv, 1275 York Ave, New York, NY 10021 USA

[10] Tulane Univ Med Ctr Hosp & Clin, Sect Hematol & Med Oncol, New Orleans, LA USA

[11] AbbVie Inc, N Chicago, IL USA

[12] Washington Univ, Sch Med, St Louis, MO 63110 USA

[13] Mayo Clin, Div Hematol, Rochester, MN USA

来源：

BLOOD | 2022年 / 140卷

关键词：

D O I：

10.1182/blood-2022-167008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：4401 / 4404

页数：4