Maternal Flavonoids Intake Reverts Depression-Like Behaviour in Rat Female Offspring

被引:42
作者
Laura de la Garza, Ana [1 ,2 ]
Garza-Cuellar, Miguel A. [3 ,4 ]
Silva-Hernandez, Ivan A. [3 ,4 ]
Cardenas-Perez, Robbi E. [4 ,5 ]
Reyes-Castro, Luis A. [6 ]
Zambrano, Elena [6 ]
Gonzalez-Hernandez, Brenda [3 ]
Garza-Ocanas, Lourdes [7 ]
Fuentes-Mera, Lizeth [4 ]
Camacho, Alberto [4 ,5 ]
机构
[1] Univ Autonoma Nuevo Leon, Fac Salud Publ & Nutr, Ctr Invest Nutr & Salud Publ, Monterrey 64460, Mexico
[2] Univ Autonoma Nuevo Leon, Ctr Res & Dev Hlth Sci, Nutr Unit, Monterrey 64460, Mexico
[3] Univ Autonoma Nuevo Leon, Fac Ciencias Biol, Dept Biochem, Monterrey 66455, Mexico
[4] Univ Autonoma Nuevo Leon, Fac Med, Dept Biochem, Monterrey 64460, Mexico
[5] Univ Autonoma Nuevo Leon, Ctr Res & Dev Hlth Sci, Neurometab Unit, Monterrey 64460, Mexico
[6] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Mexico City 14080, DF, Mexico
[7] Univ Autonoma Nuevo Leon, Fac Med, Dept Pharmacol, Monterrey 64460, Mexico
关键词
depression; nutritional programming; kaempferol; narirutin; inflammation; DIET; OBESITY; INFLAMMATION; EXPOSURE; ANXIETY; METAANALYSIS; NARINGENIN; ACTIVATION; MECHANISMS; EXPRESSION;
D O I
10.3390/nu11030572
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Maternal hypercaloric exposure during pregnancy and lactation is a risk factor for developing diseases associated with inflammation such as obesity, diabetes and, neurological diseases in the offspring. Neuroinflammation might modulate neuronal activation and flavonoids are dietary compounds that have been proven to exert anti-inflammatory properties. Thus, the aim of the present study is to evaluate the effect of maternal supplementation with flavonoids (kaempferol-3-O-glucoside and narirutin) on the prevention of depression-like behaviour in the female offspring of dams fed with an obesogenic diet during the perinatal period. Maternal programming was induced by high fat (HFD), high sugar (HSD), or cafeteria diets exposure and depressive like-behaviour, referred to as swimming, climbing, and immobility events, was evaluated around postnatal day 56-60 before and after 30 mg/kg i.p. imipramine administration in the female offspring groups. Central inflammation was analyzed by measuring the TANK binding kinase 1 (TBK1) expression. We found that the offspring of mothers exposed to HSD programming failed to show the expected antidepressant effect of imipramine. Also, imipramine injection, to the offspring of mothers exposed to cafeteria diet, displayed a pro-depressive like-behaviour phenotype. However, dietary supplementation with flavonoids reverted the depression-like behaviour in the female offspring. Finally, we found that HSD programming increases the TBK1 inflammatory protein marker in the hippocampus. Our data suggest that maternal HSD programming disrupts the antidepressant effect of imipramine whereas cafeteria diet exposure leads to depressive-like behaviour in female offspring, which is reverted by maternal flavonoid supplementation.
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页数:15
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