First total synthesis of (±)-AM6898A and (±)-AM6898D

被引：28

作者：

Fukuda, Y ^{[1
]}

Okamoto, Y ^{[1
]}

机构：

[1] Eisai & Co Ltd, Tsukuba Res Labs, Tsukuba, Ibaraki 3002635, Japan

来源：

TETRAHEDRON | 2002年 / 58卷 / 13期

关键词：

AM6898A; AM6898D; intramolecular aldol condensation; Claisen rearrangement;

D O I：

10.1016/S0040-4020(02)00155-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have established an effective method for the syntheses of (+/-)-AM6898D and its possible three diastereoisomers via Claisen rearrangement, stereoselective epimerization, and introduction of one isoprene unit by umpolung. Additionally, we have achieved the total synthesis of (+/-)-AM6898A from the same intermediate, by intramolecular aldol condensation. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2513 / 2521

页数：9

共 16 条

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