First total synthesis of (±)-AM6898A and (±)-AM6898D

被引：28
作者：
Fukuda, Y [1 ]
Okamoto, Y [1 ]
机构：
[1] Eisai & Co Ltd, Tsukuba Res Labs, Tsukuba, Ibaraki 3002635, Japan
来源：
TETRAHEDRON | 2002年 / 58卷 / 13期
关键词：
AM6898A; AM6898D; intramolecular aldol condensation; Claisen rearrangement;
D O I：
10.1016/S0040-4020(02)00155-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have established an effective method for the syntheses of (+/-)-AM6898D and its possible three diastereoisomers via Claisen rearrangement, stereoselective epimerization, and introduction of one isoprene unit by umpolung. Additionally, we have achieved the total synthesis of (+/-)-AM6898A from the same intermediate, by intramolecular aldol condensation. (C) 2002 Elsevier Science Ltd. All rights reserved.
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收藏
页码：2513 / 2521
页数：9
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