Uric Acid and Diabetes: Is there a Link?

被引：101
作者：
Katsiki, Niki [1 ]
Papanas, Nikolaos [2 ]
Fonseca, Vivian A. [3 ,4 ]
Maltezos, Efstratios [2 ]
Mikhailidis, Dimitri P. [1 ]
机构：
[1] UCL, Sch Med, Dept Clin Biochem Vasc Dis Prevent Clin, London NW3 2QG, England
[2] Democritus Univ Thrace, Dept Internal Med 2, Outpatient Clin Obes Diabet & Metab, Komotini, Greece
[3] Tulane Univ, Hlth Sci Ctr, Dept Med, New Orleans, LA 70112 USA
[4] Tulane Univ, Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA 70112 USA
来源：
CURRENT PHARMACEUTICAL DESIGN | 2013年 / 19卷 / 27期
关键词：
Uric acid; type; 1; diabetes; 2; diabetic complications; drugs; CORONARY-HEART-DISEASE; FATTY LIVER-DISEASE; ISCHEMIC NONEMBOLIC STROKE; IMPAIRED FASTING GLUCOSE; 3RD NATIONAL-HEALTH; METABOLIC SYNDROME; RENAL-FUNCTION; RISK-FACTORS; GREEK ATORVASTATIN; INSULIN-RESISTANCE;
D O I：
10.2174/1381612811319270016
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Elevated serum uric acid (SUA) levels (i.e. hyperuricaemia) have been associated with metabolic syndrome (MetS) and cardiovascular disease (CVD) morbidity and mortality. Elevated SUA levels predict the onset of type 2 diabetes (T2DM). SUA levels are increased during the early stages of impaired glucose metabolism. Furthermore, in diabetic patients, hyperuricaemia has been linked to both micro- and macrovascular complications. The present review considers: (1) SUA levels in patients with MetS, type 1 diabetes and T2DM; (2) the mechanisms that influence SUA levels in these patients; (3) the potential links between SUA and diabetic complications. The effect on SUA levels of drugs commonly prescribed for T2DM and the risk of uric acid nephrolithiasis in patients with MetS or DM are also briefly discussed.
引用
收藏
页码：4930 / 4937
页数：8
相关论文
共 145 条
[1]   Association Between Serum Uric Acid Level and Chronic Liver Disease in the United States [J].
Afzali, Anita ;
Weiss, Noel S. ;
Boyko, Edward J. ;
Ioannou, George N. .
HEPATOLOGY, 2010, 52 (02) :578-589
[2]  
AGAMAH ES, 1991, J LAB CLIN MED, V118, P241
[3]   The metabolic syndrome - a new worldwide definition [J].
Alberti, KGMM ;
Zimmet, P ;
Shaw, J .
LANCET, 2005, 366 (9491) :1059-1062
[4]  
[Anonymous], 1923, ZENT INN MED, DOI DOI 10.1002/(SICI)1096-9136(199807)15:7<539::
[5]   Effect of statin treatment on renal function and serum uric acid levels and their relation to vascular events in patients with coronary heart disease and metabolic syndrome - A subgroup analysis of the GREek Atorvastatin and Coronary heart disease Evaluation (GREACE) Study [J].
Athyros, Vasilios G. ;
Mikhailidis, Dimitri P. ;
Liberopoulos, Evangelos N. ;
Kakafika, Anna I. ;
Karagiannis, Asterios ;
Papageorgiou, Athanasios A. ;
Tziomalos, Konstantinos ;
Ganotakis, Emmanuel S. ;
Elisaf, Moses .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2007, 22 (01) :118-127
[6]   Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis [J].
Athyros, Vasilios G. ;
Tziomalos, Konstantinos ;
Gossios, Thomas D. ;
Griva, Theodora ;
Anagnostis, Panagiotis ;
Kargiotis, Konstantinos ;
Pagourelias, Efstathios D. ;
Theocharidou, Eleni ;
Karagiannis, Asterios ;
Mikhailidis, Dimitri P. .
LANCET, 2010, 376 (9756) :1916-1922
[7]   Comparison of four definitions of the metabolic syndrome in a Greek (Mediterranean) population [J].
Athyros, Vasilios G. ;
Ganotakis, Emmanuel S. ;
Tziomalos, Konstantinos ;
Papageorgiou, Athanasios A. ;
Anagnostis, Panagiotis ;
Griva, Theodora ;
Kargiotis, Konstantinos ;
Mitsiou, Eydoxia K. ;
Karagiannis, Asterios ;
Mikhailidis, Dimitri P. .
CURRENT MEDICAL RESEARCH AND OPINION, 2010, 26 (03) :713-719
[8]   Association between the changes in renal function and serum uric acid levels during multifactorial intervention and clinical outcome in patients with metabolic syndrome. A post hoc analysis of the ATTEMPT study [J].
Athyros, Vassilios G. ;
Karagiannis, Asterios ;
Ganotakis, Emmanouel S. ;
Paletas, Konstantinos ;
Nicolaou, Vassilios ;
Bacharoudis, George ;
Tziomalos, Konstantinos ;
Alexandrides, Theodore ;
Liberopoulos, Evangelos N. ;
Mikhailidis, Dimitri P. .
CURRENT MEDICAL RESEARCH AND OPINION, 2011, 27 (08) :1659-1668
[9]   The prevalence of the metabolic syndrome in Greece: the MetS-Greece Multicentre Study [J].
Athyros, VG ;
Bouloukos, VI ;
Pehlivanidis, AN ;
Papageorgiou, AA ;
Dionysopoulou, SG ;
Symeonidis, AN ;
Petridis, DI ;
Kapousouzi, MI ;
Satsoglou, EA ;
Mikhailidis, DP .
DIABETES OBESITY & METABOLISM, 2005, 7 (04) :397-405
[10]   Pathogenesis and treatment of kidney disease and hypertension - Effect of statins versus untreated dyslipidemia on serum uric acid levels in patients with coronary heart disease: A subgroup analysis of the GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) study [J].
Athyros, VG ;
Elisaf, M ;
Papageorgiou, AA ;
Symeonidis, AN ;
Pehlivanidis, AN ;
Bouloukos, VI ;
Milionis, HJ ;
Mikhailidis, DP .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2004, 43 (04) :589-599
12345678910