The association between the poly(A) polymorphism in the VDR gene and cancer risk: a meta-analysis

被引：8
作者：
Huang, Jin [1 ]
Yang, Jiqiao [1 ]
Wang, Haichuan [1 ]
Xiong, Tianyuan [1 ]
Zhang, Hongbo [2 ]
Ma, Yaxian [1 ]
Wang, Xiaoze [1 ]
Huang, Jichong [1 ]
Du, Liang [3 ]
机构：
[1] Sichuan Univ, West China Med Sch, West China Hosp, Chengdu 610041, Sichuan, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Med Sch 2, Chengdu 610000, Sichuan, Peoples R China
[3] Sichuan Univ, Period Press West China Hosp, Chengdu 610041, Sichuan, Peoples R China
来源：
TUMOR BIOLOGY | 2013年 / 34卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Vitamin D receptor; Poly(A); Polymorphism; Cancer; Meta-analysis; VITAMIN-D-RECEPTOR; PROSTATE-CANCER; BREAST-CANCER; COLORECTAL-CANCER; ANDROGEN; GROWTH;
D O I：
10.1007/s13277-013-0724-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The poly(A) polymorphism (L/S) in the VDR gene has been implicated in susceptibility of cancer, but a number of studies have reported inconclusive results. The aim of this study is to investigate the relationship between the poly(A) polymorphism in the VDR gene and cancer risk by meta-analysis. We searched PubMed database, EMBASE database, CNKI database, and Wanfang database, covering all studies until January 22, 2013. Statistical analysis was performed by using the software Revman4.2 and STATA 10.0. A total 8,186 cancer cases and 8,685 controls in 19 case-control studies from 15 studies were identified for data analysis. The results suggested that the S allele carriers (SS + SL) did not have an increased or decreased risk of cancer when compared with the homozygote LL carriers (odds ratio (OR) = 0.96, 95 % CI = 0.87-1.06, P = 0.43 for SS + SL vs. LL). In addition, in the subgroup analysis by ethnicity and cancer type, no significant association was found among Caucasians, African-Americans, prostate cancer, or breast cancer. This current meta-analysis suggested that the poly(A) polymorphism in the VDR gene may not contribute to the risk of cancer. Future studies are needed to validate our findings.
引用
收藏
页码：1833 / 1838
页数：6
相关论文
共 24 条
[1]   Vitamin D receptor FokI and BsmI gene polymorphism and its association with grade and stage of renal cell carcinoma in North Indian population [J].
Arjumand, Wani ;
Ahmad, Shiekh Tanveer ;
Seth, Amlesh ;
Saini, Ashish Kumar ;
Sultana, Sarwat .
TUMOR BIOLOGY, 2012, 33 (01) :23-31
[2]   Vitamin D receptor gene polymorphisms and colorectal cancer risk: A systematic meta-analysis [J].
Bai, Yong-Heng ;
Lu, Hong ;
Hong, Dan ;
Lin, Cheng-Cheng ;
Yu, Zhen ;
Chen, Bi-Cheng .
WORLD JOURNAL OF GASTROENTEROLOGY, 2012, 18 (14) :1672-1679
[3]   TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk [J].
Barbisan, Gisela ;
Orlando Perez, Luis ;
Contreras, Anahi ;
Daniel Golijow, Carlos .
TUMOR BIOLOGY, 2012, 33 (05) :1549-1556
[4]  
Blazer DG, 2000, MOL CARCINOGEN, V27, P18
[5]   Vitamin D receptor gene polymorphism(s) and breast cancer risk in north Indians [J].
Chakraborty, Anurupa ;
Mishra, Ashwani K. ;
Soni, Abha ;
Regina, Thodum ;
Mohil, R. ;
Bhatnagar, D. ;
Bhatnagar, A. ;
Chintamani, Chintamani ;
Sharma, P. C. ;
Saxena, Sunita .
CANCER DETECTION AND PREVENTION, 2009, 32 (5-6) :386-394
[6]  
Chang C K, 2012, J Gastrointest Cancer, V43, P512
[7]   Vitamin D receptor gene polymorphisms and prostate cancer risk [J].
Cheteri, MBK ;
Stanford, JL ;
Friedrichsen, DM ;
Peters, MA ;
Iwasaki, L ;
Langlois, MC ;
Feng, ZD ;
Ostrander, EA .
PROSTATE, 2004, 59 (04) :409-418
[8]   Vitamin D receptor polymorphisms as markers in prostate cancer [J].
Correa-Cerro, L ;
Berthon, P ;
Häussler, J ;
Bochum, S ;
Drelon, E ;
Mangin, P ;
Fournier, G ;
Paiss, T ;
Cussenot, O ;
Vogel, W .
HUMAN GENETICS, 1999, 105 (03) :281-287
[9]   The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation [J].
DeBerardinis, Ralph J. ;
Lum, Julian J. ;
Hatzivassiliou, Georgia ;
Thompson, Craig B. .
CELL METABOLISM, 2008, 7 (01) :11-20
[10]   Vitamin D receptor poly(A) microsatellite and colorectal cancer risk in Caucasians [J].
Fluegge, Jana ;
Laschinski, Gabriele ;
Roots, Ivar ;
Krusekopf, Solveigh .
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2009, 24 (02) :171-175
123