Cancer stem cells: the 'heartbeat' of gastric cancer

被引：49

作者：

Xu, Guihua ^{[1
]}

Shen, Jie ^{[2
]}

Yang, Xiaohui Ou ^{[3
]}

Sasahara, Masakiyo ^{[4
]}

Su, Xiulan ^{[1
]}

机构：

[1] Inner Mongolia Med Univ, Clin Med Res Ctr, Hohhot 010050, Inner Mongolia, Peoples R China

[2] Inner Mongolia Hosp, Dept Neurol, Hohhot, Inner Mongolia, Peoples R China

[3] Inner Mongolia Hosp, Dept Gen Surg, Hohhot, Inner Mongolia, Peoples R China

[4] Toyama Univ, Dept Pathol, Grad Sch Med & Pharmaceut Sci, Toyama 930, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2013年 / 48卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Gastric cancer; Cancer stem cell; Biomarker; Signaling pathway; Microenvironment; MARROW-DERIVED CELLS; OMENTAL MILKY SPOTS; BONE MORPHOGENETIC PROTEIN-2; HELICOBACTER-PYLORI-INFECTION; TUMOR-INITIATING CELLS; ACUTE MYELOID-LEUKEMIA; SIDE POPULATION CELLS; SONIC HEDGEHOG; MOUSE STOMACH; SELF-RENEWAL;

D O I：

10.1007/s00535-012-0712-y

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Gastric cancer (GC) remains one of the most common cancers worldwide. Its prevalence is still on the rise in the developing countries due to the ageing population. The cancer stem cell (CSC) theory provides a new insight into the interpretation of tumor initiation, aggressive growth, recurrence, and metastasis of cancer, as well as the development of new strategies for cancer treatment. This review will focus on the progress of biomarkers and signaling pathways of CSCs, the complex crosstalk networks between the microenvironment and CSCs, and the development of therapeutic approaches against CSCs, predominantly focusing on GC.

引用

页码：781 / 797

页数：17

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