Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics

被引：40

作者：

Kupcewicz, Bogumila ^{[1
]}

Sobiesiak, Krzysztof ^{[1
]}

Malinowska, Katarzyna ^{[2
]}

Koprowska, Kamila ^{[3
]}

Czyz, Malgorzata ^{[3
]}

Keppler, Bernhard ^{[4
]}

Budzisz, Elzbieta ^{[1
,5
]}

机构：

[1] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Fac Pharm, Dept Inorgan & Analyt Chem, PL-85094 Bydgoszcz, Poland

[2] Med Univ Lodz, Dept Chem & Clin Biochem, PL-90647 Lodz, Poland

[3] Med Univ Lodz, Dept Mol Biol Canc, PL-92215 Lodz, Poland

[4] Univ Vienna, Inst Inorgan Chem, A-1090 Vienna, Austria

[5] Med Univ Lodz, Fac Pharm, Dept Cosmet Raw Mat Chem, PL-90151 Lodz, Poland

来源：

MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 05期

关键词：

Enzyme mimic; Copper(II) complexes; Pyrazoles; Reactive oxygen species; Cyclic voltammetry; SUPEROXIDE-DISMUTASE; CYTOTOXIC ACTIVITY; ANTITUMOR-ACTIVITY; CRYSTAL-STRUCTURE; IN-VITRO; PALLADIUM(II); PLATINUM(II); LIGANDS; PEROXIDASE; MEPIRIZOLE;

D O I：

10.1007/s00044-012-0233-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of six mononuclear Cu(II) complexes with pyrazole-based ligands: 5-(2-hydroxybenzoyl)-3-methyl-1-(2-pyridinyl)-1H-pyrazol-4-phosphonic acid dimethyl ester (1a), 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridylo)-1H-pyrazole-4-carboxylic acid methyl ester (1b) and 1-benzothiazol-2-yl-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester (1c) were characterized regarding to electrochemical and antioxidant properties. All complexes exhibit suitable Cu(II)/Cu(I) redox potential (E (1/2)) to act as antioxidant enzymes mimic. The five of these complexes were found to be trifunctional enzyme mimics possessing SOD, CAT and GPx-like catalytic activities. Moreover, Cu(II) complexes were capable to decrease ROS level in melanoma cells and observed effects were not merely a reflection of cytotoxicity.

引用

页码：2395 / 2402

页数：8

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