Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics

被引：40

作者：

Kupcewicz, Bogumila ^{[1
]}

Sobiesiak, Krzysztof ^{[1
]}

Malinowska, Katarzyna ^{[2
]}

Koprowska, Kamila ^{[3
]}

Czyz, Malgorzata ^{[3
]}

Keppler, Bernhard ^{[4
]}

Budzisz, Elzbieta ^{[1
,5
]}

机构：

[1] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Fac Pharm, Dept Inorgan & Analyt Chem, PL-85094 Bydgoszcz, Poland

[2] Med Univ Lodz, Dept Chem & Clin Biochem, PL-90647 Lodz, Poland

[3] Med Univ Lodz, Dept Mol Biol Canc, PL-92215 Lodz, Poland

[4] Univ Vienna, Inst Inorgan Chem, A-1090 Vienna, Austria

[5] Med Univ Lodz, Fac Pharm, Dept Cosmet Raw Mat Chem, PL-90151 Lodz, Poland

来源：

MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 05期

关键词：

Enzyme mimic; Copper(II) complexes; Pyrazoles; Reactive oxygen species; Cyclic voltammetry; SUPEROXIDE-DISMUTASE; CYTOTOXIC ACTIVITY; ANTITUMOR-ACTIVITY; CRYSTAL-STRUCTURE; IN-VITRO; PALLADIUM(II); PLATINUM(II); LIGANDS; PEROXIDASE; MEPIRIZOLE;

D O I：

10.1007/s00044-012-0233-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of six mononuclear Cu(II) complexes with pyrazole-based ligands: 5-(2-hydroxybenzoyl)-3-methyl-1-(2-pyridinyl)-1H-pyrazol-4-phosphonic acid dimethyl ester (1a), 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridylo)-1H-pyrazole-4-carboxylic acid methyl ester (1b) and 1-benzothiazol-2-yl-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester (1c) were characterized regarding to electrochemical and antioxidant properties. All complexes exhibit suitable Cu(II)/Cu(I) redox potential (E (1/2)) to act as antioxidant enzymes mimic. The five of these complexes were found to be trifunctional enzyme mimics possessing SOD, CAT and GPx-like catalytic activities. Moreover, Cu(II) complexes were capable to decrease ROS level in melanoma cells and observed effects were not merely a reflection of cytotoxicity.

引用

页码：2395 / 2402

页数：8

共 50 条

[1] Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics
Bogumiła Kupcewicz
Krzysztof Sobiesiak
Katarzyna Malinowska
Kamila Koprowska
Malgorzata Czyz
Bernhard Keppler
Elżbieta Budzisz
Medicinal Chemistry Research, 2013, 22 : 2395 - 2402
[2] Copper(II) complexes with pyrazole derivatives - Synthesis, crystal structure, DFT calculations and cytotoxic activity
Kupcewicz, Bogumila
Ciolkowski, Michal
Karwowski, Boleslaw T.
Rozalski, Marek
Krajewska, Urszula
Lorenz, Ingo-Peter
Mayer, Peter
Budzisz, Elzbieta
JOURNAL OF MOLECULAR STRUCTURE, 2013, 1052 : 32 - 37
[3] Synthesis, characterization, and antitumor activities of two copper(II) complexes with pyrazole derivatives
Ruan, Ban-Feng
Liang, Yun-Ke
Liu, Wan-Ding
Wu, Jie-Ying
Tian, Yu-Peng
JOURNAL OF COORDINATION CHEMISTRY, 2012, 65 (12) : 2127 - 2134
[4] Copper(II) complexes with terpene derivatives of ethylenediamine: synthesis, and antibacterial, antifungal and antioxidant activity
Gur'eva, Yana A.
Zalevskaya, Olga A.
Shevchenko, Oksana G.
Slepukhin, Pavel A.
Makarov, Vadim A.
Kuchin, Aleksandr, V
RSC ADVANCES, 2022, 12 (15) : 8841 - 8851
[5] Synthesis, physico-chemical properties and biological analysis of newly obtained copper(II) complexes with pyrazole derivatives
Grazul, Magdalena
Besic-Gyenge, Emina
Maake, Caroline
Ciolkowski, Michal
Czyz, Malgorzata
Sigel, Roland K. O.
Budzisz, Elzbieta
JOURNAL OF INORGANIC BIOCHEMISTRY, 2014, 135 : 68 - 76
[6] Synthesis, properties and structure of copper(II) complexes of quinolyl azo derivatives of pyrazole-5-one(thione)
Uraev, Ali I.
Lyssenko, Konstantin A.
Vlasenko, Valery G.
Zubavichus, Yan V.
Bubnov, Michael P.
Makarova, Nadezhda I.
Garnovskii, Dmitrii A.
Burlov, Anatolii S.
POLYHEDRON, 2018, 146 : 1 - 11
[7] Copper(II) complexes of hydroxyflavone derivatives as potential bioactive molecule to combat antioxidants: synthesis, characterization and pharmacological activities
Nagashri, K.
Joseph, J.
Dhanaraj, C. Justin
APPLIED ORGANOMETALLIC CHEMISTRY, 2011, 25 (09) : 704 - 717
[8] Copper(II) complexes as superoxide dismutase mimics: Synthesis, characterization, crystal structure and bioactivity of copper(II) complexes
Patel, R. N.
Shukla, K. K.
Singh, Anurag
Choudhary, M.
Chauhan, U. K.
Dwivedi, S.
INORGANICA CHIMICA ACTA, 2009, 362 (14) : 4891 - 4898
[9] COPPER(II) COMPLEXES OF HYDRAZONE DERIVATIVES
SOUZA, P
MENDIOLA, MA
ARQUERO, A
FERNANDEZ, V
GUTIERREZPUEBLA, E
RUIZVALERO, C
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 1994, 49 (02): : 263 - 271
[10] Copper complexes bearing 2-aminobenzothiazole derivatives as potential antioxidant: Synthesis, characterization
Joseph, J.
Janaki, G. Boomadevi
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2016, 162 : 86 - 92

← 1 2 3 4 5 →