A catalyst- and solvent-free thermal multicomponent approach for the construction of diverse and polysubstituted 2-aminopyridines and their antibacterial activity

被引：14
|
作者：
Baral, Ek Raj [1 ]
Sharma, Kavita [1 ]
Akhtar, Muhammad Saeed [1 ]
Lee, Yong Rok [1 ]
机构：
[1] Yeungnam Univ, Sch Chem Engn, Gyongsan 712749, South Korea
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 43期
基金：
新加坡国家研究基金会;
关键词：
DERIVATIVES; ANNULATION; AMINATION; DISCOVERY; EFFICIENT; ACCESS; AGENTS;
D O I：
10.1039/c6ob02015a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient and facile thermal multicomponent cascade reaction of readily available 4-oxo-4H-chromene-3-carbaldehydes with cyanoacetates or cyanoamides and anilines or aliphatic amines under solvent and catalyst-free conditions was developed for the synthesis of a range of polysubstituted 2-aminopyridine derivatives in good to excellent yield. This protocol proceeds via a cascade reaction of Knoevenagel condensation, nucleophilic addition, intramolecular Michael addition, and ring opening. As an application of this methodology, the antibacterial activities of some of the synthetic compounds were evaluated.
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页码：10285 / 10297
页数：13
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