A catalyst- and solvent-free thermal multicomponent approach for the construction of diverse and polysubstituted 2-aminopyridines and their antibacterial activity

被引：14

作者：

Baral, Ek Raj ^{[1
]}

Sharma, Kavita ^{[1
]}

Akhtar, Muhammad Saeed ^{[1
]}

Lee, Yong Rok ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Chem Engn, Gyongsan 712749, South Korea

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 43期

基金：

新加坡国家研究基金会;

关键词：

DERIVATIVES; ANNULATION; AMINATION; DISCOVERY; EFFICIENT; ACCESS; AGENTS;

D O I：

10.1039/c6ob02015a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient and facile thermal multicomponent cascade reaction of readily available 4-oxo-4H-chromene-3-carbaldehydes with cyanoacetates or cyanoamides and anilines or aliphatic amines under solvent and catalyst-free conditions was developed for the synthesis of a range of polysubstituted 2-aminopyridine derivatives in good to excellent yield. This protocol proceeds via a cascade reaction of Knoevenagel condensation, nucleophilic addition, intramolecular Michael addition, and ring opening. As an application of this methodology, the antibacterial activities of some of the synthetic compounds were evaluated.

引用

收藏

页码：10285 / 10297

页数：13

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