The antifungal activity of graphene oxide-silver nanocomposites

被引：227
作者：
Li, Chao [1 ]
Wang, Xiansong [1 ]
Chen, Feng [1 ]
Zhang, Chunlei [1 ]
Zhi, Xiao [1 ]
Wang, Kan [1 ]
Cui, Daxiang [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Res Inst Micro Nano Sci & Technol, Minist Educ, Dept Bionano Sci & Engn,Key Lab Thin Film & Micro, Shanghai 200240, Peoples R China
来源：
BIOMATERIALS | 2013年 / 34卷 / 15期
基金：
中国国家自然科学基金;
关键词：
Graphene oxide; Carbon nanoscrolls; Silver nanopartides; Antifungal activity; Controlled drug release; ANODE MATERIAL; NANOPARTICLES; SHEETS; REDUCTION; RELEASE; CARBON; NANOMATERIALS; CYTOTOXICITY; CAPACITY; STORAGE;
D O I：
10.1016/j.biomaterials.2013.02.001
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Graphene oxide (GO)-based nanocomposites' antibacteria activity exhibits great potential in clinical application. Herein we reported for the first time the preparation and enhanced antifungal activity of carbon nanoscrolls (CNSs) filled with silver nanoparticles (AgNPs). The nanoscrolls filled with silver nanoparticles were prepared by sonication, TEM picture showed AgNPs filled and wrapped inside prepared nanocomposites, the antifungal test showed that CNSs-AgNPs exhibited ideal lengthened activities against Candida albicans and Candida tropical compared with the GO-AgNPs nanocomposites based on silver nanoparticles directly deposited on the surface of grapheme oxides, which is caused by CNS-AgNPs' controlled durative slow-releasing of silver ion. It is also observed that graphene oxides exhibited no antifungal activity. In conclusion, the carbon nanoscrolls composed of graphene oxides and silver nanoparticles own enhanced and lengthened antifungal activity, and have great potential in applications such as clinical nosocomial infections and local antifungal therapy. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3882 / 3890
页数：9
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