The Kras2 oncogene and mouse lung carcinogenesis

被引：7

作者：

Lee, Gang-Hong ^{[1
]}

机构：

[1] Kochi Univ, Sch Med, Dept Pathol, Nanko Ku, Kochi 7838505, Japan

来源：

MEDICAL MOLECULAR MORPHOLOGY | 2008年 / 41卷 / 04期

基金：

日本学术振兴会;

关键词：

Kras2; Mouse; Lung; Cancer; Adenocarcinoma; Susceptibility; Genetics;

D O I：

10.1007/s00795-008-0419-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Activating point mutations of the mouse Kras2 oncogene or its human homologue, KRAS, are critical for lung adenocarcinoma genesis, independent of the species. Significantly, in the mouse, several polymorphic Kras2 alleles have been identified, which cosegregate with genetic susceptibility to chemical induction of lung tumors. Moreover, a major lung tumor susceptibility locus, the Pas1 (Pulmonary adenoma susceptibility 1), was found to colocalize with Kras2 on distal chromosome 6 on linkage analysis. The Kras2 may thus be involved in both cellular transformation and genetic control of tumor susceptibility. In this review, the focus is on current knowledge regarding the relationship between Kras2 and experimental mouse lung carcinogenesis, especially from the aspect of disease predisposition. Because mouse and human lung tumors share considerable similarities, the experimental information should provide clues to personalized medicine in the human setting.

引用

页码：199 / 203

页数：5

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