A brainwide atlas of synapses across the mouse life span

被引：109
作者：
Cizeron, Melissa [1 ,2 ]
Qiu, Zhen [1 ]
Koniaris, Babis [1 ,3 ]
Gokhale, Ragini [1 ]
Komiyama, Noboru H. [1 ,4 ]
Fransen, Erik [5 ,6 ]
Grant, Seth G. N. [1 ,4 ]
机构：
[1] Univ Edinburgh, Genes Cognit Program, Ctr Clin Brain Sci, Edinburgh EH16 4SB, Midlothian, Scotland
[2] Univ Claude Bernard Lyon 1, Univ Lyon, Inst NeuroMyoGene, CNRS,INSERM,U1217,UMR 5310, F-69008 Lyon, France
[3] Edinburgh Napier Univ, Sch Comp, Edinburgh EH10 5DT, Midlothian, Scotland
[4] Univ Edinburgh, Ctr Discovery Brain Sci, Simons Initiat Developing Brain SIDB, Edinburgh EH8 9XD, Midlothian, Scotland
[5] KTH Royal Inst Technol, Sch Elect Engn & Comp Sci, Dept Computat Sci & Technol, S-10044 Stockholm, Sweden
[6] KTH Royal Inst Technol, Sci Life Lab, SE-17165 Solna, Sweden
来源：
SCIENCE | 2020年 / 369卷 / 6501期
基金：
英国惠康基金; 欧洲研究理事会;
关键词：
LONG-TERM POTENTIATION; POSTSYNAPTIC DENSITY-95; SYNAPTIC PLASTICITY; NMDA RECEPTORS; CORTEX; DIFFERENTIATION; ABILITIES; COMPLEX;
D O I：
10.1126/science.aba3163
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Synapses connect neurons together to form the circuits of the brain, and their molecular composition controls innate and learned behavior. We analyzed the molecular and morphological diversity of 5 billion excitatory synapses at single-synapse resolution across the mouse brain from birth to old age. A continuum of changes alters synapse composition in all brain regions across the life span. Expansion in synapse diversity produces differentiation of brain regions until early adulthood, and compositional changes cause dedifferentiation in old age. The spatiotemporal synaptome architecture of the brain potentially accounts for life-span transitions in intellectual ability, memory, and susceptibility to behavioral disorders. © 2020 American Association for the Advancement of Science. All rights reserved.
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页码：270 / +
页数：86
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