Amphiphilic block co-polymers: Preparation and application in nanodrug and gene delivery

被引：90
|
作者：
Xiong, Xiao-Bing [1 ]
Binkhathlan, Ziyad [1 ,2 ]
Molavi, Ommoleila [1 ]
Lavasanifar, Afsaneh [1 ,3 ]
机构：
[1] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada
[2] King Saud Univ, Coll Pharm, Dept Pharmaceut, Nanomed Res Unit, Riyadh 11451, Saudi Arabia
[3] Univ Alberta, Dept Chem & Mat Engn, Edmonton, AB T6G 2V4, Canada
来源：
ACTA BIOMATERIALIA | 2012年 / 8卷 / 06期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Drug delivery; Nanotechnology; Polymeric micelles; Block co-polymers; Drug targeting; RING-OPENING POLYMERIZATION; POLYION COMPLEX MICELLES; HETEROBIFUNCTIONAL POLY(ETHYLENE GLYCOL); INTRACELLULAR DRUG-DELIVERY; ENZYME-CATALYZED SYNTHESIS; AMINO-ACID; ONE END; CONTROLLED-RELEASE; IN-VITRO; LIVING POLYMERIZATION;
D O I：
10.1016/j.actbio.2012.03.006
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Self-assembly of amphiphilic block co-polymers composed of poly(ethylene oxide) (PEO) as the hydrophilic block and poly(ether)s, poly(amino acid)s, poly(ester)s and polypropyleneoxide (PPO) as the hydrophobic block can lead to the formation of nanoscopic structures of different morphologies. These structures have been the subject of extensive research in the past decade as artificial mimics of lipoproteins and viral vectors for drug and gene delivery. The aim of this review is to provide an overview of the synthesis of commonly used amphiphilic block co-polymers. It will also briefly go over some pharmaceutical applications of amphiphilic block co-polymers as "nanodelivery systems" for small molecules and gene therapeutics. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：2017 / 2033
页数：17
相关论文
共 50 条
  • [41] THE THEORY OF ADSORPTION OF REGULAR BLOCK CO-POLYMERS ON THE INTERPHASE
    ZHULINA, YB
    SKVORTSOV, AM
    BIRSHTEIN, TM
    VYSOKOMOLEKULYARNYE SOEDINENIYA SERIYA A, 1981, 23 (02): : 304 - 312
  • [42] SYNTHESIS OF ORGANOSILOXANE BLOCK CO-POLYMERS VIA INTERFACIAL
    RIFFLE, JS
    BANTHIA, A
    WEBSTER, DC
    MCGRATH, JE
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1980, 179 (MAR): : 20 - ORPL
  • [43] REINFORCED NYLON 6-BLOCK CO-POLYMERS
    GABBERT, JD
    GARNER, AY
    HEDRICK, RM
    POLYMER COMPOSITES, 1983, 4 (03) : 196 - 199
  • [44] Fluorinated Polyphenylenevinylene (PPV) Block Co-Polymers for Nanophotonics
    Sun, Sam-Shajing
    Thuong Nguyen
    Brooks, Jaleesa
    NANOPHOTONICS AND MACROPHOTONICS FOR SPACE ENVIRONMENTS VII, 2013, 8876
  • [45] ON INTERACTION OF PHASES OF PROPYLENE - ETHYLENE BLOCK CO-POLYMERS
    POPOV, VP
    MARTYNOV, MA
    VYSOKOMOLEKULYARNYE SOEDINENIYA SERIYA B, 1982, 24 (12): : 894 - 898
  • [46] BLOCK CO-POLYMERS WITH HIGHLY ORIENTED LAMELLAR MORPHOLOGY
    ANNIGHOFER, F
    GRONSKI, W
    MAKROMOLEKULARE CHEMIE-RAPID COMMUNICATIONS, 1983, 4 (03): : 123 - 127
  • [47] SYNTHESIS OF BLOCK CO-POLYMERS CONTAINING A CARBON CHAIN AND A POLYPEPTIDE BLOCK
    VLASOV, GP
    RUDKOVSKAYA, GD
    OVSYANNIKOVA, LA
    MAKROMOLEKULARE CHEMIE-MACROMOLECULAR CHEMISTRY AND PHYSICS, 1982, 183 (11): : 2635 - 2644
  • [48] Amphiphilic Block Copolymer Micelles for Gene Delivery
    Li Qin
    Jin Bixin
    Luo Yunjun
    Li Xiaoyu
    CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2022, 38 (06) : 1368 - 1379
  • [49] Amphiphilic Block Copolymer Micelles for Gene Delivery
    Qin Li
    Bixin Jin
    Yunjun Luo
    Xiaoyu Li
    Chemical Research in Chinese Universities, 2022, 38 : 1368 - 1379
  • [50] STYRENE-DIVINYL BENZENE CO-POLYMERS .26. PROPERTIES OF STYRENE DIVINYL BENZENE BLOCK CO-POLYMERS
    POPOV, G
    SCHWACHULA, G
    PLASTE UND KAUTSCHUK, 1983, 30 (04): : 193 - 195
12345