Amphiphilic block co-polymers: Preparation and application in nanodrug and gene delivery

被引：90

作者：

Xiong, Xiao-Bing ^{[1
]}

Binkhathlan, Ziyad ^{[1
,2
]}

Molavi, Ommoleila ^{[1
]}

Lavasanifar, Afsaneh ^{[1
,3
]}

机构：

[1] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada

[2] King Saud Univ, Coll Pharm, Dept Pharmaceut, Nanomed Res Unit, Riyadh 11451, Saudi Arabia

[3] Univ Alberta, Dept Chem & Mat Engn, Edmonton, AB T6G 2V4, Canada

来源：

ACTA BIOMATERIALIA | 2012年 / 8卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Drug delivery; Nanotechnology; Polymeric micelles; Block co-polymers; Drug targeting; RING-OPENING POLYMERIZATION; POLYION COMPLEX MICELLES; HETEROBIFUNCTIONAL POLY(ETHYLENE GLYCOL); INTRACELLULAR DRUG-DELIVERY; ENZYME-CATALYZED SYNTHESIS; AMINO-ACID; ONE END; CONTROLLED-RELEASE; IN-VITRO; LIVING POLYMERIZATION;

D O I：

10.1016/j.actbio.2012.03.006

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Self-assembly of amphiphilic block co-polymers composed of poly(ethylene oxide) (PEO) as the hydrophilic block and poly(ether)s, poly(amino acid)s, poly(ester)s and polypropyleneoxide (PPO) as the hydrophobic block can lead to the formation of nanoscopic structures of different morphologies. These structures have been the subject of extensive research in the past decade as artificial mimics of lipoproteins and viral vectors for drug and gene delivery. The aim of this review is to provide an overview of the synthesis of commonly used amphiphilic block co-polymers. It will also briefly go over some pharmaceutical applications of amphiphilic block co-polymers as "nanodelivery systems" for small molecules and gene therapeutics. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：2017 / 2033

页数：17

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