Recent application of oxa-Michael reaction in complex natural product synthesis

被引：77

作者：

Hu, Jialei ^{[1
]}

Bian, Ming ^{[2
]}

Ding, Hanfeng ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China

[2] Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 50期

基金：

中国国家自然科学基金;

关键词：

Domino reactions; Natural products; Oxa-Michael addition; Synthetic strategy; Total synthesis; DIASTEREOSELECTIVE TOTAL-SYNTHESIS; ENANTIOSELECTIVE TOTAL-SYNTHESIS; CDEF RING-SYSTEM; LIVERWORT PALLAVICINIA-SUBCILIATA; PROPOSED AZASPIRACID-1 STRUCTURE; DINOFLAGELLATE AMPHIDINIUM SP; ASYMMETRIC TOTAL-SYNTHESIS; SPONGE CORTICIUM-SIMPLEX; CONCISE TOTAL-SYNTHESIS; BOND-FORMING REACTIONS;

D O I：

10.1016/j.tetlet.2016.11.007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The strategy of employing oxa-Michael reaction in today's organic synthesis appears to be a big success due to its high efficiency in the construction of C-O bonds. In this digest, recent advances of its application in the total synthesis of representative oxygen-containing natural products, involving macrolides, terpenoids, chromanones and chromanes, polyoxygenated molecules and alkaloids et al. are discussed, with the aim of providing a complement to existing reviews. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：5519 / 5539

页数：21

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