Parallel adaptation of rabbit populations to myxoma virus

被引：114

作者：

Alves, Joel M. ^{[1
,2
,3
]}

Carneiro, Miguel ^{[2
,4
]}

Cheng, Jade Y. ^{[5
,6
,7
]}

de Matos, Ana Lemos ^{[8
]}

Rahman, Masmudur M. ^{[8
]}

Loog, Liisa ^{[3
,9
]}

Campos, Paula F. ^{[7
,10
]}

Wales, Nathan ^{[7
,11
,12
]}

Eriksson, Anders ^{[13
]}

Manica, Andrea ^{[14
]}

Strive, Tanja ^{[15
,16
]}

Graham, Stephen C. ^{[17
]}

Afonso, Sandra ^{[2
]}

Bell, Diana J. ^{[18
]}

Belmont, Laura ^{[8
]}

Day, Jonathan P. ^{[1
]}

Fuller, Susan J. ^{[19
]}

Marchandeau, Stephane ^{[20
]}

Palmer, William J. ^{[21
,22
]}

Queney, Guillaume ^{[23
]}

Surridge, Alison K. ^{[18
]}

Vieira, Filipe G. ^{[7
]}

McFadden, Grant ^{[8
]}

Nielsen, Rasmus ^{[5
,6
,7
]}

Gilbert, M. Thomas P. ^{[7
,24
]}

Esteves, Pedro J. ^{[2
,25
]}

Ferrand, Nuno ^{[2
,4
,26
]}

Jiggins, Francis M. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

[2] Univ Porto, InBIO Lab Associado, Ctr Invest Biodiversidade & Recursos Genet, CIBIO, P-4485661 Vairao, Portugal

[3] Univ Oxford, Palaeogen & Bioarchaeol Res Network, Res Lab Archaeol & Hist Art, Dyson Perrins Bldg,South Parks Rd, Oxford OX1 3QY, England

[4] Univ Porto, Fac Ciencias, Dept Biol, P-4169007 Porto, Portugal

[5] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA

[6] Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA

[7] Univ Copenhagen, Ctr GeoGenet, Nat Hist Museum Denmark, DK-1350 Copenhagen, Denmark

[8] Arizona State Univ, Ctr Immunotherapy Vaccines & Virotherapy, Biodesign Inst, Tempe, AZ 85287 USA

[9] Univ Manchester, Manchester Inst Biotechnol, Sch Earth & Environm Sci, Manchester M1 7DN, Lancs, England

[10] Univ Porto, Interdisciplinary Ctr Marine & Environm Res, CIIMAR, Ave Gen Norton Matos S-N, P-4450208 Matosinhos, Portugal

[11] Univ Calif Berkeley, Dept Plant & Microbial Biol, 111 Koshland Hall, Berkeley, CA 94720 USA

[12] Univ York, Dept Archaeol, York YO1 7EP, N Yorkshire, England

[13] Kings Coll London, Dept Med & Mol Genet, London SE1 9RT, England

[14] Univ Cambridge, Dept Zool, Downing St, Cambridge CB2 3EJ, England

[15] Commonwealth Sci & Ind Res Org, Hlth Biosecur, Canberra, ACT 2601, Australia

[16] Univ Canberra, Ctr Invas Species Solut, Bruce, ACT 2601, Australia

[17] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

[18] Univ East Anglia, Sch Biol Sci, Ctr Ecol Evolut & Conservat, Norwich NR4 7TJ, Norfolk, England

[19] Queensland Univ Technol, Sci & Engn Fac, Sch Earth Environm & Biol Sci, Brisbane, Qld, Australia

[20] Off Natl Chasse & Faune Sauvage, Nantes, France

[21] Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA

[22] Univ Calif Davis, Dept Plant Sci, Davis, CA 95616 USA

[23] ANTAGENE, Wildlife Genet Lab, Lyon, France

[24] Univ Museum, Norwegian Univ Sci & Technol, N-7491 Trondheim, Norway

[25] Inst Invest Formacao & Avancada Ciencias & Tecnol, Gandra, Portugal

[26] Univ Johannesburg, Fac Sci, Dept Zool, ZA-2006 Auckland Pk, South Africa

来源：

SCIENCE | 2019年 / 363卷 / 6433期

基金：

欧洲研究理事会; 英国惠康基金; 美国国家卫生研究院;

关键词：

WILD RABBITS; RECEPTOR; DISEASE; DNA; PROTEINS; ACTIVATION; RESISTANCE; AUSTRALIA; EVOLUTION; SELECTION;

D O I：

10.1126/science.aau7285

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein's antiviral effect.

引用

页码：1319 / +

页数：50

共 61 条

[1] Rabbit haemorrhagic disease (RHD) and rabbit haemorrhagic disease virus (RHDV): a review [J].

Abrantes, Joana ;

van der Loo, Wessel ;

Le Pendu, Jacques ;

Esteves, Pedro J. .

VETERINARY RESEARCH, 2012, 43

[2]

Alves J., 2019, PARALLEL ADAPTATION

[3]

Alves J. M., 2019, VARIANT CALLS ASS PA, DOI [10.17863/CAM.35707, DOI 10.17863/CAM.35707]

[4]

Andrews S., 2010, QC FAST QUALITY CONT

[5]

[Anonymous], 1965, Myxomatosis

[6]

[Anonymous], MAPS DRAW GEOGRAPHIC

[7]

[Anonymous], MAPDATA EXTRA MAP DA

[8] Trimmomatic: a flexible trimmer for Illumina sequence data [J].

Bolger, Anthony M. ;

Lohse, Marc ;

Usadel, Bjoern .

BIOINFORMATICS, 2014, 30 (15) :2114-2120

[9] ALINE: a WYSIWYG protein-sequence alignment editor for publication-quality alignments [J].

Bond, Charles Simon ;

Schuettelkopf, Alexander Wolfgang .

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2009, 65 :510-512

[10] Patterns of damage in genomic DNA sequences from a Neandertal [J].

Briggs, Adrian W. ;

Stenzel, Udo ;

Johnson, Philip L. F. ;

Green, Richard E. ;

Kelso, Janet ;

Pruefer, Kay ;

Meyer, Matthias ;

Krause, Johannes ;

Ronan, Michael T. ;

Lachmann, Michael ;

Paeaebo, Svante .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (37) :14616-14621

← 1 2 3 4 5 6 7 →