Receptor for Advanced Glycation End Products Regulates Leukotriene B4 Receptor 1 Signaling

Leukotriene B-4 receptor 1 (BLT1), a high-affinity G protein-coupled receptor (GPCR) for leukotriene B-4 (LTB4), plays important roles in inflammatory and immune reactions. Although the LTB4-BLT1 axis is known to promote inflammation, the binding proteins that modulate LTB4-BLT1 signaling have not been identified. Recently, we discovered that receptor for advanced glycation end products (RAGE) interacts with BLT1 and modulates LTB4-BLT1 signaling. We propose RAGE as a new class of GPCR modulator and a new target of future GPCR studies.