Receptor for Advanced Glycation End Products Regulates Leukotriene B4 Receptor 1 Signaling

被引：7

作者：

Ichiki, Takako ^{[1
]}

Koga, Tomoaki ^{[1
,2
]}

Yokomizo, Takehiko ^{[1
]}

机构：

[1] Juntendo Univ, Dept Biochem, Sch Med, Tokyo, Japan

[2] Kumamoto Univ, Program Leading Grad Sch, Hlth Life Sci Interdisciplinary & Glocal Oriented, Prior Org Innovat & Excellence, Kumamoto, Japan

来源：

DNA AND CELL BIOLOGY | 2016年 / 35卷 / 12期

关键词：

receptor for advanced glycation end products; leukotriene B-4 receptor 1; G protein-coupled receptor; KAPPA-B; EOSINOPHIL ACCUMULATION; NEUTROPHIL RECRUITMENT; MICE REVEALS; RAGE; ATHEROSCLEROSIS; INFLAMMATION; BLT2; CHEMOTAXIS; PROTEINS;

D O I：

10.1089/dna.2016.3552

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leukotriene B-4 receptor 1 (BLT1), a high-affinity G protein-coupled receptor (GPCR) for leukotriene B-4 (LTB4), plays important roles in inflammatory and immune reactions. Although the LTB4-BLT1 axis is known to promote inflammation, the binding proteins that modulate LTB4-BLT1 signaling have not been identified. Recently, we discovered that receptor for advanced glycation end products (RAGE) interacts with BLT1 and modulates LTB4-BLT1 signaling. We propose RAGE as a new class of GPCR modulator and a new target of future GPCR studies.

引用

页码：747 / 750

页数：4

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