Recent Advances and Applications of Experimental Technologies in Marine Natural Product Research

被引：28

作者：

Li, Ke ^{[1
]}

Chung-Davidson, Yu-Wen ^{[1
]}

Bussy, Ugo ^{[1
]}

Li, Weiming ^{[1
]}

机构：

[1] Michigan State Univ, Dept Fisheries & Wildlife, E Lansing, MI 48824 USA

来源：

MARINE DRUGS | 2015年 / 13卷 / 05期

关键词：

marine organism; sampling strategies; nanoscale NMR; computational chemistry; UNIVERSAL NMR DATABASE; STEREOCHEMICAL ASSIGNMENT; HPLC-NMR; ABSOLUTE-CONFIGURATION; STRUCTURE ELUCIDATION; CHEMICAL-SHIFTS; DRUG DISCOVERY; PSYCHROTROPHIC BACTERIA; CIRCULAR-DICHROISM; ORGANIC-MOLECULES;

D O I：

10.3390/md13052694

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Marine natural products are a rich source of novel and biologically active compounds. The number of identified marine natural compounds has grown 20% over the last five years from 2009 to 2013. Several challenges, including sample collection and structure elucidation, have limited the development of this research field. Nonetheless, new approaches, such as sampling strategies for organisms from extreme ocean environments, nanoscale NMR and computational chemistry for structural determination, are now available to overcome the barriers. In this review, we highlight the experimental technology innovations in the field of marine natural products, which in our view will lead to the development of many new drugs in the future.

引用

页码：2694 / 2713

页数：20

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