Yoropyrazone, a new naphthopyridazone alkaloid isolated from Streptomyces sp IFM 11307 and evaluation of its TRAIL resistance-overcoming activity

被引:31
作者
Abdelfattah, Mohamed S. [2 ]
Toume, Kazufumi
Ishibashi, Masami [1 ]
机构
[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chuo Ku, Chiba 2608675, Japan
[2] Helwan Univ, Fac Sci, Dept Chem, Cairo, Egypt
基金
日本学术振兴会;
关键词
naphthopyridazone; Streptomyces sp; TRAIL; NATURAL-PRODUCTS; ANTIBIOTICS; DERIVATIVES; MECHANISMS;
D O I
10.1038/ja.2012.11
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A new naphthopyridazone derivative, yoropyrazone (1), has been isolated from Streptomyces sp. IFM 11307. The structure of the new compound was established on the basis of spectroscopic analyses. Compound 1 (10 mu M) in combination with TRAIL moderately showed cytotoxic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma (AGS) cells. The Journal of Antibiotics (2012) 65, 245-248; doi:10.1038/ja.2012.11; published online 22 February 2012
引用
收藏
页码:245 / 248
页数:4
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