Modeling a system of phosphated cross-linked high amylose for controlled drug release. Part 1: Synthesis and polymer characterization

被引：14

作者：

Cury, B. S. F. ^{[1
]}

Klein, S. A. ^{[2
]}

Evangelista, R. C. ^{[1
]}

机构：

[1] Sao Paulo State Univ, Fac Pharmaceut Sci, Grad Program Pharmaceut Sci, UNESP, BR-14801902 Araraquara, SP, Brazil

[2] Sao Paulo State Univ, Inst Chem, Dept Gen & Inorgan Chem, UNESP, BR-14800900 Araraquara, SP, Brazil

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2008年 / 68卷 / 08期

关键词：

high amylose; cross-linking; sodium trimetaphosphate; reaction kinetics;

D O I：

10.1016/j.reactfunctpolym.2008.04.003

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

High amylose was cross-linked with sodium trimetaphosphate (STMP) using 2% and 4% solutions of NaOH at room temperature with reaction contact times of 0.5, 1, 2 and 4 h. The different polymers obtained were analyzed by FT IR, C-13 and P-31 solid state NMR, SEM and C, H and P elemental analysis. The results were used to propose a two-stage mechanism for phosphate incorporation, the first being kinetically controlled. (C) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1200 / 1206

页数：7

相关论文

共 22 条

[1] Na-23, Al-27 and P-31 NMR and X-ray powder diffraction study of Na/Ca/Al phosphate glasses and ceramics [J].

Abrahams, I ;

Franks, K ;

Hawkes, GE ;

Philippou, G ;

Knowles, J ;

Bodart, P ;

Nunes, T .

JOURNAL OF MATERIALS CHEMISTRY, 1997, 7 (08) :1573-1580

[2] Cross-linked cellulose as a tablet excipient: A binding/disintegrating agent [J].

Chebli, C ;

Cartilier, L .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1998, 171 (01) :101-110

[3] Substituted amylose as a matrix for sustained drug release [J].

Chebli, C ;

Moussa, I ;

Buczkowski, S ;

Cartilier, L .

PHARMACEUTICAL RESEARCH, 1999, 16 (09) :1436-1440

[4] Effect of some physical parameters on the sustained drug-release properties of substituted amylose matrices [J].

Chebli, C ;

Cartilier, L .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2000, 193 (02) :167-173

[5] Characterization of crosslinked high amylose starch matrix implants -: 2.: In vivo release of ciprofloxacin [J].

Désévaux, C ;

Lenaerts, V ;

Girard, C ;

Dubreuil, P .

JOURNAL OF CONTROLLED RELEASE, 2002, 82 (01) :95-103

[6] Synthesis and characterization of cross-linked chitosan microspheres for drug delivery applications [J].

Dini, E ;

Alexandridou, S ;

Kiparissides, C .

JOURNAL OF MICROENCAPSULATION, 2003, 20 (03) :375-385

[7] Cross-linked amylose as matrix for drug controlled release. X-ray and FT-IR structural analysis [J].

Dumoulin, Y ;

Alex, S ;

Szabo, P ;

Cartilier, L ;

Mateescu, MA .

CARBOHYDRATE POLYMERS, 1998, 37 (04) :361-370

[8]

GIL VMS, 1987, RESSONANCIA MAGNETIC, P779

[9] Phosphated crosslinked guar for colon-specific drug delivery I. Preparation and physicochemical characterization [J].

Gliko-Kabir, I ;

Yagen, B ;

Penhasi, A ;

Rubinstein, A .

JOURNAL OF CONTROLLED RELEASE, 2000, 63 (1-2) :121-127

[10] ANALYSIS OF RAT-HEART INVIVO BY PHOSPHORUS NUCLEAR MAGNETIC-RESONANCE [J].

GROVE, TH ;

ACKERMAN, JJH ;

RADDA, GK ;

BORE, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (01) :299-302