Extract of Oenothera biennis L. stem inhibits LPS-induced inflammation by regulating MAPK and NF-κB signaling pathways

被引：7

作者：

Ma, Rui ^{[2
]}

Chen, Qi ^{[2
]}

Li, He ^{[2
]}

Wu, Songquan ^{[1
,2
]}

Lian, Meilan ^{[1
,2
]}

Jin, Xin ^{[2
]}

Jiang, Jun ^{[1
,2
]}

机构：

[1] Yanbian Univ, Key Lab Nat Resource Changbai Mt & Funct Mol, Minist Educ, Yanji, Jilin, Peoples R China

[2] Yanbian Univ, Agr Coll, Yanji, Jilin, Peoples R China

来源：

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2020年 / 33卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Oenothera biennis L. stems; anti-inflammation; MAPK; NF-kappa B; resource utilization; EVENING PRIMROSE OENOTHERA; OIL; ANTIOXIDANT; SUPPLEMENTATION; FLAVONOIDS; ACTIVATION;

D O I：

10.36721/PJPS.2020.33.4.REG.1473-1481.1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oenothera biennis L. is a perennial herb distributed across America, Asia, and Europe. The pharmacological effect of Oenothera biennis L. stem is poorly understood. We demonstrated that lipopolysaccharide (LPS)-induced the high production of inflammatory mediators nitric oxide (NO) and prostaglandin E-2 (PGE(2)), and the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1 beta in peritoneal macrophages (PMs) were significantly inhibited by the crude extract The inflammation related signaling extra cellular signal-regulated ERK, P38 of MAPK and NF-kappaB (NF-kappa B) activated by LPS dramatically inhibited. In conclusion, our results suggested that the stems of Oenothera biennis L.possess a high anti-inflammatory property, thus, can be used in the industrial production of medicinal products as the raw material in the future.

引用

页码：1473 / 1481

页数：9

共 38 条

[1] The screening of selected South African medicinal plants for total phenolics, flavonoids and anti-inflammatory properties
Adebayo, S. A.
Shai, L. J.
Eloff, J. N.
[J]. SOUTH AFRICAN JOURNAL OF BOTANY, 2013, 86 : 148 - 148
[2] Bayles B, 2009, AM FAM PHYSICIAN, V80, P1405
[3] BRZESKI M, 1991, BRIT J RHEUMATOL, V30, P370
[4] HORMONAL AND BIOCHEMICAL PROFILES OF PREMENSTRUAL-SYNDROME - TREATMENT WITH ESSENTIAL FATTY-ACIDS
CERIN, A
COLLINS, A
LANDGREN, BM
ENEROTH, P
[J]. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 1993, 72 (05) : 337 - 343
[5] Church B, 2006, LULU
[6] Phenolic compounds in olive oil and olive pomace from Cilento (Campania, Italy) and their antioxidant activity
Cioffi, Giuseppina
Pesca, Maria Sabina
De Caprariis, Paolo
Braca, Alessandra
Severino, Lorella
De Tommasi, Nunziatina
[J]. FOOD CHEMISTRY, 2010, 121 (01) : 105 - 111
[7] Pulmonary fibrosis: cytokines in the balance
Coker, RK
Laurent, GJ
[J]. EUROPEAN RESPIRATORY JOURNAL, 1998, 11 (06) : 1218 - 1221
[8] Production of adventitious roots and secondary metabolites by Hypericum perforatum L. in a bioreactor
Cui, Xi-Hua
Chakrabarty, Debasis
Lee, Eun-Jung
Paek, Kee-Yoeup
[J]. BIORESOURCE TECHNOLOGY, 2010, 101 (12) : 4708 - 4716
[9] Chemical Composition, Antioxidative and Anti-Inflammatory Activity of Extracts Prepared from Aerial Parts of Oenothera biennis L. and Oenothera paradoxa Hudziok Obtained after Seeds Cultivation
Granica, Sebastian
Czerwinska, Monika E.
Piwowarski, Jakub P.
Ziaja, Maria
Kiss, Anna K.
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2013, 61 (04) : 801 - 810
[10] Anti-inflammatory action of Athyrium multidentatum extract suppresses the LPS-induced TLR4 signaling pathway
Han, Xiong-Zhe
Ma, Rui
Chen, Qi
Jin, Xin
Jin, Yuan-Zhe
An, Ren-Bo
Piao, Xuan-Mei
Lian, Mei-Lan
Quan, Lin-Hu
Jiang, Jun
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2018, 217 : 220 - 227

← 1 2 3 4 →