Pharmacokinetics of mirtazapine and its main metabolites in Beagle dogs: A pilot study

被引：31

作者：

Giorgi, Mario ^{[1
]}

Yun, Hyoin ^{[2
]}

机构：

[1] Univ Pisa, Vet Teaching Hosp, Dept Vet Clin, I-56122 Pisa, Italy

[2] Chungnam Natl Univ, Inst Vet Sci, Coll Vet Med, Taejon 305764, South Korea

来源：

VETERINARY JOURNAL | 2012年 / 192卷 / 02期

关键词：

Mirtazapine; Metabolites; Beagle dogs; Pharmacokinetics; Oral administration; ANTIDEPRESSANT MIRTAZAPINE; SEPARATION ANXIETY; ANIMAL-MODELS; TABLETS;

D O I：

10.1016/j.tvjl.2011.05.010

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Mirtazapine (MRT) is a human antidepressant drug mainly metabolised by the cytochrome P450 enzyme system to 8-OH mirtazapine (8-OH) and dimetilmirtazapine (DMR). The drug is usually administered to dogs with anorexia according to doses extrapolated from humans, although it could also have applications as an antidepressant and analgesic in this species. The aim of this study was to assess the pharmacokinetics of MRT and its metabolites, DMT and 8-OH. Six healthy male Beagle dogs were administered MRT orally (20 mg/dog) and plasma MRT and metabolite concentrations were evaluated by high performance liquid chromatography with fluorescence detection. The pharmacokinetic profiles of MRT and DMR were similar (detected from 0.25 up to 10 h), while 8-OH (detected from 0.50 up to 10 h) attained the highest concentrations. The mean half-life of MRT was 6.17 h with a clearance of 1193 mL/h/kg. The study showed that MRT has a different pharmacokinetic profile in the dog compared to other species. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：239 / 241

页数：3

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