Ferrocene-pyrimidine conjugates: Synthesis, electrochemistry, physicochemical properties and antiplasmodial activities

被引：41

作者：

Chopra, Rakesh ^{[1
]}

de Kock, Carmen ^{[2
]}

Smith, Peter ^{[2
]}

Chibale, Kelly ^{[3
,4
]}

Singh, Kamaljit ^{[1
]}

机构：

[1] Guru Nanak Dev Univ, Dept Chem, UGC Ctr Adv Studies 2, Amritsar 143005, Punjab, India

[2] Univ Cape Town, Div Pharmacol, Dept Med, ZA-7925 Observatory, South Africa

[3] Univ Cape Town, Dept Chem, South African Med Res Council Drug Discovery, Inst Infect Dis & Mol Med, ZA-701 Rondebosch, South Africa

[4] Univ Cape Town, Dev Res Unit, Inst Infect Dis & Mol Med, ZA-701 Rondebosch, South Africa

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 100卷

基金：

英国医学研究理事会;

关键词：

Ferrocene conjugates; Ferrocene/ferrocenium redox couple; Huisgen 1,3-dipolar cycloaddition; Antiplasmodial studies; Lipophilicity; PLASMODIUM-FALCIPARUM MALARIA; ANTIMALARIAL ACTIVITY; IN-VITRO; CHLOROQUINE RESISTANCE; ORGANOMETALLIC ANALOG; FERROQUINE; 4-AMINOQUINOLINE; DRUG; HYBRIDS; ARTEMISININ;

D O I：

10.1016/j.ejmech.2015.05.043

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The promise of hybrid antimalarial agents and the precedence set by the antimalarial drug ferroquine prompted us to design ferrocene-pyrimidine conjugates. Herein, we report the synthesis, electrochemistry and anti-plasmodial evaluation of ferrocenyl-pyrimidine conjugates against chloroquine susceptible NF54 strain of the malaria parasite Plasmodium falciparum. Also their physicochemical properties have been studied. (C) 2015 Elsevier Masson SAS. All rights reserved.

引用

页码：1 / 9

页数：9

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