Neural immune modulation and immunotherapy assisted by focused ultrasound induced blood-brain barrier opening

被引：26

作者：

Chen, Pin-Yuan ^{[1
,2
]}

Wei, Kuo-Chen ^{[1
,2
]}

Liu, Hao-Li ^{[3
,4
]}

机构：

[1] Chang Gung Univ, Dept Neurosurg, Chang Gung Mem Hosp, Linkou Med Ctr, Taoyuan, Taiwan

[2] Chang Gung Univ, Coll Med, Taoyuan, Taiwan

[3] Chang Gung Univ, Dept Elect Engn, Taoyuan, Taiwan

[4] Chang Gung Univ, Chang Gung Mem Hosp, Inst Radiol Res, Med Imaging Res Ctr, Taoyuan, Taiwan

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2015年 / 11卷 / 11期

关键词：

blood-brain barrier; focused ultrasound; immune modulation; immunotherapy; DELIVERY; CELLS; DISRUPTION; SYSTEM; INTERLEUKIN-2; INFLAMMATION; ANTIBODY;

D O I：

10.1080/21645515.2015.1071749

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The central nervous system (CNS) has long been regarded as an immune-privileged site, with the blood-brain barrier (BBB) limiting the entering of systemic immune cells and components. Exposure of low-energy focused ultrasound (FUS) with the presence of microbubbles has been found to provide a temporary and targeted opening of the BBB without inflicting brain damage or inflammation, and is thus an attractive means of delivering CNS therapeutic agents and raising the potential for targeted CNS immunotherapy. Based on our recent studies on enhancing brain-tumor immune-related therapy via this mechanism,(1) we summarize current approaches using FUS-induced BBB opening to promote immune regulation and project potential directions for FUS-induced CNS immunotherapy.

引用

页码：2682 / 2687

页数：6

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