An expedient synthesis of pyrrolidinyl spirooxindole grafted 3-nitrocluomanes through 1,3-dipolar cycloaddition reaction of azomethine ylides

被引：39
作者：
Rao, J. Naga Siva [1 ]
Raghunathan, R. [1 ]
机构：
[1] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 48期
关键词：
1,3-Dipole; Cycloaddition; Azomethine ylide; Pyrrolidinyl-spirooxindole; 3-Nitrochromenes; STRUCTURE-BASED DESIGN; DOPAMINE D-3; INTRAMOLECULAR CYCLOADDITION; ENANTIOSELECTIVE SYNTHESIS; POTENT; CONSTRUCTION; ANTAGONIST; INHIBITORS; RECEPTORS; (+/-)-HORSFILINE;
D O I：
10.1016/j.tetlet.2013.09.097
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile one-pot synthesis of pyrrolidinyl-spirooxindole grafted 3-nitrochromanes has been accomplished by 1,3-dipolar cycloaddition (1,3-DC) reaction of 3-nitrochromenes with azomethine ylides generated in situ from isatin and secondary amino acids. The regio- and stereochemical outcome of the cycloaddition reaction was ascertained by X-ray crystallographic analysis. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6568 / 6573
页数：6
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