An expedient synthesis of pyrrolidinyl spirooxindole grafted 3-nitrocluomanes through 1,3-dipolar cycloaddition reaction of azomethine ylides

被引：39

作者：

Rao, J. Naga Siva ^{[1
]}

Raghunathan, R. ^{[1
]}

机构：

[1] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 48期

关键词：

1,3-Dipole; Cycloaddition; Azomethine ylide; Pyrrolidinyl-spirooxindole; 3-Nitrochromenes; STRUCTURE-BASED DESIGN; DOPAMINE D-3; INTRAMOLECULAR CYCLOADDITION; ENANTIOSELECTIVE SYNTHESIS; POTENT; CONSTRUCTION; ANTAGONIST; INHIBITORS; RECEPTORS; (+/-)-HORSFILINE;

D O I：

10.1016/j.tetlet.2013.09.097

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile one-pot synthesis of pyrrolidinyl-spirooxindole grafted 3-nitrochromanes has been accomplished by 1,3-dipolar cycloaddition (1,3-DC) reaction of 3-nitrochromenes with azomethine ylides generated in situ from isatin and secondary amino acids. The regio- and stereochemical outcome of the cycloaddition reaction was ascertained by X-ray crystallographic analysis. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：6568 / 6573

页数：6

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