Do Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SIVD) progress differently?

被引：13
作者：
Hong, Yun Jeong [1 ]
Yoon, Bora [2 ]
Shim, Yong S. [3 ]
Han, Il-Woo [1 ]
Han, Seol-Heui [4 ]
Park, Kee Hyung [5 ]
Choi, Seong Hye [6 ]
Ku, Bon D. [7 ]
Yang, Dong Won [3 ]
机构：
[1] Yong In Hyoja Geriatr Hosp, Dept Neurol, Yongin 446769, South Korea
[2] Konyang Univ, Dept Neurol, Coll Med, Taejon 302718, South Korea
[3] Catholic Univ Korea, Dept Neurol, Coll Med, Seoul 137701, South Korea
[4] Konkuk Univ, Dept Neurol, Sch Med, Seoul 143729, South Korea
[5] Gachon Univ, Gil Med Ctr, Dept Neurol, Inchon 405760, South Korea
[6] Inha Univ, Sch Med, Dept Neurol, Inchon 400711, South Korea
[7] Kwandong Univ, Coll Med, Dept Neurol, Myongji Hosp, Goyang 412826, South Korea
来源：
ARCHIVES OF GERONTOLOGY AND GERIATRICS | 2014年 / 58卷 / 03期
关键词：
AD; Cognitive neuropsychology; Disease progression; SVD; SIVD; DEPRESSIVE SYMPTOMS; SUBTYPES; STROKE;
D O I：
10.1016/j.archger.2013.11.005
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Our study aimed to compare cognitive status and declines in AD with/without small vessel disease (SVD) and SIVD at baseline and 1-year follow-up. Patients with Alzheimer's disease without small vessel disease (AD(-) SVD) (n = 148), Alzheimer's disease with small vessel disease (AD(+) SVD) (n = 94) and SIVD (n = 60) were recruited from database of multiple centers in Korea. Basic demographics and detailed neuropsychological results were compared. AD, regardless of SVD, showed worse memory and better executive function than SIVD at baseline. Mini-Mental State Examination scores and visual memory function declined more in AD than those in SIVD whereas Barthel Activities of Daily Living (B-ADL) scores declined more in SIVD. AD showed different patterns of cognitive impairment compared with SIVD. After 1 year, AD showed more rapid cognitive decline in some domains. Further investigations with longer follow-up duration may be needed to confirm the cumulative effects of SVD in AD and different patterns of decline between AD and SIVD. (C) 2013 Published by Elsevier Ireland Ltd.
引用
收藏
页码：415 / 419
页数：5
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