Circular RNAs: Characterization, cellular roles, and applications

被引：637

作者：

Liu, Chu-Xiao ^{[1
]}

Chen, Ling-Ling ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Mol Biol, Shanghai, Peoples R China

[2] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China

[3] Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Hangzhou, Peoples R China

来源：

CELL | 2022年 / 185卷 / 12期

基金：

中国博士后科学基金; 国家重点研发计划; 中国国家自然科学基金;

关键词：

EXON CIRCULARIZATION; CERNA HYPOTHESIS; NONCODING RNA; PROTEIN; INTRON; TRANSLATION; REVEALS; ACTIVATION; BIOGENESIS; EXPRESSION;

D O I：

10.1016/j.cell.2022.04.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Most circular RNAs are produced from the back-splicing of exons of precursor mRNAs. Recent technological advances have in part overcome problems with their circular conformation and sequence overlap with linear cognate mRNAs, allowing a better understanding of their cellular roles. Depending on their localization and specific interactions with DNA, RNA, and proteins, circular RNAs can modulate transcription and splicing, regulate stability and translation of cytoplasmic mRNAs, interfere with signaling pathways, and serve as templates for translation in different biological and pathophysiological contexts. Emerging applications of RNA circles to interfere with cellular processes, modulate immune responses, and direct translation into proteins shed new light on biomedical research. In this review, we discuss approaches used in circular RNA studies and the current understanding of their regulatory roles and potential applications.

引用

页码：2016 / 2034

页数：19

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