Estimated Glomerular Filtration Rate, All-Cause Mortality and Cardiovascular Diseases Incidence in a Low Risk Population: The MATISS Study

被引:39
作者
Donfrancesco, Chiara [1 ]
Palleschi, Simonetta [2 ]
Palmieri, Luigi [1 ]
Rossi, Barbara [2 ]
Lo Noce, Cinzia [1 ]
Pannozzo, Fabio [3 ]
Spoto, Belinda [4 ]
Tripepi, Giovanni [4 ]
Zoccali, Carmine [3 ]
Giampaoli, Simona [1 ]
机构
[1] Ist Super Sanita, Natl Ctr Epidemiol Surveillance & Hlth Promot, I-00161 Rome, Italy
[2] Ist Super Sanita, Dept Hematol Oncol & Mol Med, I-00161 Rome, Italy
[3] AUSL, Latina, Italy
[4] IBIM, CNT, Reggio Di Calabria, Italy
来源
PLOS ONE | 2013年 / 8卷 / 10期
关键词
CHRONIC KIDNEY-DISEASE; CREATININE MEASUREMENT; RENAL-FUNCTION; ASSOCIATION; ALBUMINURIA; PREDICTION; EQUATION; SMOKING; PROFILE; WOMEN;
D O I
10.1371/journal.pone.0078475
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Chronic kidney disease (CKD) independently increases the risk of death and cardiovascular disease (CVD) in the general population. However, the relationship between estimated glomerular filtration rate (eGFR) and CVD/death risk in a general population at low risk of CVD has not been explored so far. Design: Baseline and longitudinal data of 1465 men and 1459 women aged 35-74 years participating to the MATISS study, an Italian general population cohort, were used to evaluate the role of eGFR in the prediction of all-cause mortality and incident CVD. Methods: Bio-bank stored sera were used to evaluate eGFR at baseline. Serum creatinine was measured on thawed samples by means of an IDMS-calibrated enzymatic method. eGFR was calculated by the CKD-EPI formula. Results: At baseline, less than 2% of enrolled persons had eGFR < 60 mL/min/1.73m(2) and more than 70% had a 10-year cardiovascular risk score < 10%. In people 60 or more years old, the first and the last eGFR quintiles (< 90 and >= 109 mL/min/1.73m(2), respectively) were associated to an increased risk for both all-cause mortality (hazard ratio 1.6, 95% confidence interval 1.2-2.1 and 4.3, 1.6-11.7, respectively) and incident CVD (1.6, 1.0-2.4 and 7.0, 2.2-22.9, respectively), even if adjusted for classical risk factors. Conclusions: These findings strongly suggest that in an elderly, general population at low risk of CVD and low prevalence of reduced renal filtration, even a modest eGFR reduction is related to all-cause mortality and CVD incidence, underlying the potential benefit to this population of considering eGFR for their risk prediction.
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