Type 2 Innate Lymphocytes in Allergic Airway Inflammation

被引：35

作者：

Wolterink, Roel G. J. Klein ^{[1
,2
,3
,4
]}

Hendriks, Rudi W. ^{[1
]}

机构：

[1] Erasmus MC, Dept Pulm Med, NL-3000 CA Rotterdam, Netherlands

[2] Inst Pasteur, Innate Immun Unit, F-75724 Paris, France

[3] Inst Pasteur, INSERM, U668, F-75724 Paris, France

[4] Univ Paris Diderot, Sorbonne Paris Cite, F-75015 Paris, France

来源：

CURRENT ALLERGY AND ASTHMA REPORTS | 2013年 / 13卷 / 03期

关键词：

Innate lymphoid cells (ILC); Allergic airway inflammation; Mouse models; Cytokines; IL-5; IL-13; IL-25; IL-33; TSLP; Gata3; HDM; House dust mite; Influenza; Type 2 innate lymphocytes; RECEPTOR ACCESSORY PROTEIN; TRANSCRIPTION FACTOR GATA3; GENOME-WIDE ASSOCIATION; EPIDERMAL-GROWTH-FACTOR; LYMPHOID-CELLS; T-CELLS; ADAPTIVE IMMUNITY; LUNG INFLAMMATION; MAST-CELLS; IN-VIVO;

D O I：

10.1007/s11882-013-0346-z

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

CD4(+) T helper-2 (Th2) cells, which produce a unique profile of IL-4, IL-5 and IL-13 pro-inflammatory cytokines, are thought to be central in the orchestration and amplification of allergic asthma. However, a novel non-T/non-B lymphoid cell population, named type 2 innate lymphocytes (ILC2s), that produces high amounts of IL-5 and IL-13 was recently discovered. Unlike Th2 cells, these ILC2s are not antigen-restricted and are activated by epithelial cell-derived cytokines IL-25 and IL-33. In this review, we will focus on recent studies, mainly involving allergen-based mouse models, that have provided evidence for a significant contribution of ILC2 to allergic airway information.

引用

页码：271 / 280

页数：10

共 97 条

[41] Recognition of bacterial glycosphingolipids by natural killer T cells [J].

Kinjo, Y ;

Wu, D ;

Kim, GS ;

Xing, GW ;

Poles, MA ;

Ho, DD ;

Tsuji, M ;

Kawahara, K ;

Wong, CH ;

Kronenberg, M .

NATURE, 2005, 434 (7032) :520-525

[42] Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system [J].

Kondo, Yuichi ;

Yoshimoto, Tomohiro ;

Yasuda, Koubun ;

Futatsugi-Yumikura, Shizue ;

Morimoto, Mai ;

Hayashi, Nobuki ;

Hoshino, Tomoaki ;

Fujimoto, Jiro ;

Nakanishi, Kenji .

INTERNATIONAL IMMUNOLOGY, 2008, 20 (06) :791-800

[43] IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4 [J].

Kurowska-Stolarska, Mariola ;

Kewin, Pete ;

Murphy, Grace ;

Russo, Remo C. ;

Stolarski, Bartosz ;

Garcia, Cristiana Couto ;

Komai-Koma, Mousa ;

Pitman, Nick ;

Li, Yubin ;

McKenzie, Andrew N. J. ;

Teixeira, Mauro M. ;

Liew, Foo Y. ;

Xu, Damo .

JOURNAL OF IMMUNOLOGY, 2008, 181 (07) :4780-4790

[44] Infection with Influenza Virus Induces IL-33 in Murine Lungs [J].

Le Goffic, Ronan ;

Arshad, Muhammad Imran ;

Rauch, Michel ;

L'Helgoualc'h, Annie ;

Delmas, Bernard ;

Piquet-Pellorce, Claire ;

Samson, Michel .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2011, 45 (06) :1125-1132

[45] Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFκB [J].

Lee, Hai-Chon ;

Ziegler, Steven F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) :914-919

[46] Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity [J].

Liang, Hong-Erh ;

Reinhardt, R. Lee ;

Bando, Jennifer K. ;

Sullivan, Brandon M. ;

Ho, I-Cheng ;

Locksley, Richard M. .

NATURE IMMUNOLOGY, 2012, 13 (01) :58-U83

[47] Functions of T cells in asthma: more than just TH2 cells [J].

Lloyd, Clare M. ;

Hessel, Edith M. .

NATURE REVIEWS IMMUNOLOGY, 2010, 10 (12) :838-848

[48] T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function [J].

Löhning, M ;

Stroehmann, A ;

Coyle, AJ ;

Grogan, JL ;

Lin, S ;

Gutierrez-Ramos, JC ;

Levinson, D ;

Radbruch, A ;

Kamradt, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (12) :6930-6935

[49] Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease [J].

Maneechotesuwan, Kittipong ;

Yao, Xin ;

Ito, Kazuhiro ;

Jazrawi, Elen ;

Usmani, Omar S. ;

Adcock, Ian M. ;

Barnes, Peter J. .

PLOS MEDICINE, 2009, 6 (05)

[50] Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections [J].

Mattner, J ;

DeBord, KL ;

Ismail, N ;

Goff, RD ;

Cantu, C ;

Zhou, DP ;

Saint-Mezard, P ;

Wang, V ;

Gao, Y ;

Yin, N ;

Hoebe, K ;

Schneewind, O ;

Walker, D ;

Beutler, B ;

Teyton, L ;

Savage, PB ;

Bendelac, A .

NATURE, 2005, 434 (7032) :525-529

← 1 2 3 4 5 6 7 8 9 10 →