Type 2 Innate Lymphocytes in Allergic Airway Inflammation

被引：35

作者：

Wolterink, Roel G. J. Klein ^{[1
,2
,3
,4
]}

Hendriks, Rudi W. ^{[1
]}

机构：

[1] Erasmus MC, Dept Pulm Med, NL-3000 CA Rotterdam, Netherlands

[2] Inst Pasteur, Innate Immun Unit, F-75724 Paris, France

[3] Inst Pasteur, INSERM, U668, F-75724 Paris, France

[4] Univ Paris Diderot, Sorbonne Paris Cite, F-75015 Paris, France

来源：

CURRENT ALLERGY AND ASTHMA REPORTS | 2013年 / 13卷 / 03期

关键词：

Innate lymphoid cells (ILC); Allergic airway inflammation; Mouse models; Cytokines; IL-5; IL-13; IL-25; IL-33; TSLP; Gata3; HDM; House dust mite; Influenza; Type 2 innate lymphocytes; RECEPTOR ACCESSORY PROTEIN; TRANSCRIPTION FACTOR GATA3; GENOME-WIDE ASSOCIATION; EPIDERMAL-GROWTH-FACTOR; LYMPHOID-CELLS; T-CELLS; ADAPTIVE IMMUNITY; LUNG INFLAMMATION; MAST-CELLS; IN-VIVO;

D O I：

10.1007/s11882-013-0346-z

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

CD4(+) T helper-2 (Th2) cells, which produce a unique profile of IL-4, IL-5 and IL-13 pro-inflammatory cytokines, are thought to be central in the orchestration and amplification of allergic asthma. However, a novel non-T/non-B lymphoid cell population, named type 2 innate lymphocytes (ILC2s), that produces high amounts of IL-5 and IL-13 was recently discovered. Unlike Th2 cells, these ILC2s are not antigen-restricted and are activated by epithelial cell-derived cytokines IL-25 and IL-33. In this review, we will focus on recent studies, mainly involving allergen-based mouse models, that have provided evidence for a significant contribution of ILC2 to allergic airway information.

引用

页码：271 / 280

页数：10

共 97 条

[1] Human CD1-restricted T cell recognition of lipids from pollens [J].

Agea, E ;

Russano, A ;

Bistoni, O ;

Mannucci, R ;

Nicoletti, I ;

Corazzi, L ;

Postle, AD ;

De Libero, G ;

Porcelli, SA ;

Spinozzi, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (02) :295-308

[2] A role for TSLP in the development of inflammation in an asthma model [J].

Al-Shami, A ;

Spolski, R ;

Kelly, J ;

Keane-Myers, A ;

Leonard, WJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (06) :829-839

[3] IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells [J].

Ali, Shafaqat ;

Hubert, Michael ;

Kollewe, Christian ;

Bischoff, Stephan C. ;

Falk, Werner ;

Martin, Michael U. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (47) :18660-18665

[4] Interleukin 25 promotes the initiation of proallergic type 2 responses [J].

Angkasekwinai, Pornpimon ;

Park, Heon ;

Wang, Yui-Hsi ;

Wang, Yi-Hong ;

Chang, Seon Hee ;

Corry, David B. ;

Liu, Yong-Jun ;

Zhu, Zhou ;

Dong, Chen .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (07) :1509-1517

[5] Regulation of IL-9 expression by IL-25 signaling [J].

Angkasekwinai, Pornpimon ;

Chang, Seon Hee ;

Thapa, Manoj ;

Watarai, Hiroshi ;

Dong, Chen .

NATURE IMMUNOLOGY, 2010, 11 (03) :250-U9

[6] PERIPHERAL MACROPHAGE ABNORMALITIES IN MUTANT MICE WITH SPINOCEREBELLAR DEGENERATION [J].

BAKALIAN, A ;

KOPMELS, B ;

MESSER, A ;

FRADELIZI, D ;

DELHAYEBOUCHAUD, N ;

WOLLMAN, E ;

MARIANI, J .

RESEARCH IN IMMUNOLOGY, 1992, 143 (01) :129-139

[7] Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma [J].

Ballantyne, Sarah J. ;

Barlow, Jillian L. ;

Jolin, Helen E. ;

Nath, Puneeta ;

Williams, Alison S. ;

Chung, Kian Fan ;

Sturton, Graham ;

Wong, See Heng ;

McKenzie, Andrew N. J. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 120 (06) :1324-1331

[8] Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity [J].

Barlow, Jillian L. ;

Bellosi, Agustin ;

Hardman, Clare S. ;

Drynan, Lesley F. ;

Wong, See Heng ;

Cruickshank, James P. ;

McKenzie, Andrew N. J. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (01) :191-U275

[9] Pathophysiology of allergic inflammation [J].

Barnes, Peter J. .

IMMUNOLOGICAL REVIEWS, 2011, 242 :31-50

[10] IL-33-Responsive Lineage-CD25+CD44hi Lymphoid Cells Mediate Innate Type 2 Immunity and Allergic Inflammation in the Lungs [J].

Bartemes, Kathleen R. ;

Iijima, Koji ;

Kobayashi, Takao ;

Kephart, Gail M. ;

McKenzie, Andrew N. ;

Kita, Hirohito .

JOURNAL OF IMMUNOLOGY, 2012, 188 (03) :1503-1513

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