Extracellular vesicles shuffling intercellular messages: for good or for bad

被引：384

作者：

Lo Cicero, Alessandra ^{[1
,2
]}

Stahl, Philip D. ^{[3
]}

Raposo, Graca ^{[1
,2
]}

机构：

[1] PSL Res Univ, Inst Curie, F-75248 Paris, France

[2] CNRS, UMR144, Struct & Membrane Compartments, F-75248 Paris, France

[3] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2015年 / 35卷

关键词：

EXOSOME SECRETION; MULTIVESICULAR BODIES; ENDOTHELIAL-CELLS; PROGENITOR CELLS; MICRORNA; PROTEINS; MICROVESICLES; COMMUNICATION; BIOGENESIS; MECHANISMS;

D O I：

10.1016/j.ceb.2015.04.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The release of extracellular vesicles (EVs) is a highly conserved process exploited by diverse organisms as a mode of intercellular communication. Vesicles of sizes ranging from 30 to 1000 nm, or even larger, are generated by blebbing of the plasma membrane (microvesicles) or formed in multivesicular endosomes (MVEs) to be secreted by exocytosis as exosomes. Exosomes, microvesicles and other EVs contain membrane and cytosolic components that include proteins, lipids and RNAs, a composition that differs related to their site of biogenesis. Several mechanisms are involved in vesicle formation at the plasma membrane or in endosomes, which is reflected in their heterogeneity, size and composition. EVs have significant promise for therapeutics and diagnostics and for understanding physiological and pathological processes all of which have boosted research to find modulators of their composition, secretion and targeting.

引用

页码：69 / 77

页数：9

共 86 条

[1] Schwann Cell-Derived Exosomes Enhance Axonal Regeneration in the Peripheral Nervous System [J].

Alejandra Lopez-Verrilli, Maria ;

Picou, Frederic ;

Court, Felipe A. .

GLIA, 2013, 61 (11) :1795-1806

[2] Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[3] Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction [J].

Barile, Lucio ;

Lionetti, Vincenzo ;

Cervio, Elisabetta ;

Matteucci, Marco ;

Gherghiceanu, Mihaela ;

Popescu, Laurentiu M. ;

Torre, Tiziano ;

Siclari, Francesco ;

Moccetti, Tiziano ;

Vassalli, Giuseppe .

CARDIOVASCULAR RESEARCH, 2014, 103 (04) :530-541

[4] Drosophila S2 Cells Secrete Wingless on Exosome-Like Vesicles but the Wingless Gradient Forms Independently of Exosomes [J].

Beckett, Karen ;

Monier, Solange ;

Palmer, Lucy ;

Alexandre, Cyrille ;

Green, Hannah ;

Bonneil, Eric ;

Raposo, Graca ;

Thibault, Pierre ;

Le Borgne, Roland ;

Vincent, Jean-Paul .

TRAFFIC, 2013, 14 (01) :82-96

[5] Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases? [J].

Bellingham, Shayne A. ;

Guo, Belinda B. ;

Coleman, Bradley M. ;

Hill, Andrew F. .

FRONTIERS IN PHYSIOLOGY, 2012, 3

[6] Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation [J].

Bobrie, Angelique ;

Colombo, Marina ;

Krumeich, Sophie ;

Raposo, Graca ;

Thery, Clotilde .

JOURNAL OF EXTRACELLULAR VESICLES, 2012, 1 (01)

[7] Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression [J].

Bobrie, Angelique ;

Krumeich, Sophie ;

Reyal, Fabien ;

Recchi, Chiara ;

Moita, Luis F. ;

Seabra, Miguel C. ;

Ostrowski, Matias ;

Thery, Clotilde .

CANCER RESEARCH, 2012, 72 (19) :4920-4930

[8] Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses [J].

Bobrie, Angelique ;

Colombo, Marina ;

Raposo, Graca ;

Thery, Clotilde .

TRAFFIC, 2011, 12 (12) :1659-1668

[9] Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways [J].

Boelens, Mirjam C. ;

Wu, Tony J. ;

Nabet, Barzin Y. ;

Xu, Bihui ;

Qiu, Yu ;

Yoon, Taewon ;

Azzam, Diana J. ;

Victor, Christina Twyman-Saint ;

Wiemann, Brianne Z. ;

Ishwaran, Hemant ;

ter Brugge, Petra J. ;

Jonkers, Jos ;

Slingerland, Joyce ;

Minn, Andy J. .

CELL, 2014, 159 (03) :499-513

[10] Distinct lipid compositions of two types of human prostasomes [J].

Brouwers, Jos F. ;

Aalberts, Marian ;

Jansen, Jeroen W. A. ;

van Niel, Guillaume ;

Wauben, Marca H. ;

Stout, Tom A. E. ;

Helms, J. Bernd ;

Stoorvogel, Willem .

PROTEOMICS, 2013, 13 (10-11) :1660-1666

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