The role of inflammatory cytokines and tumor associated macrophages (TAMs) in microenvironment of pancreatic cancer

被引：108

作者：

Valilou, Saeed Farajzadeh ^{[1
]}

Keshavarz-Fathi, Mahsa ^{[1
,2
,3
]}

Silvestris, Nicola ^{[4
,5
,6
]}

Argentiero, Antonella ^{[4
,6
]}

Rezaei, Nima ^{[3
,7
,8
]}

机构：

[1] USERN, CIP, Tehran, Iran

[2] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran

[3] Univ Tehran Med Sci, Childrens Med Ctr, Res Ctr Immunodeficiencies, Tehran, Iran

[4] Natl Canc Inst IRCCS Giovanni Paolo II, Med Oncol Unit, Bari, Italy

[5] Natl Canc Inst IRCCS Giovanni Paolo II, Sci Directorate, Bari, Italy

[6] USERN, CIP, Bari, Italy

[7] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[8] USERN, CIP, Sheffield, S Yorkshire, England

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2018年 / 39卷

关键词：

Pancreatic cancer; Tumor microenvironment; Inflammatory cytokines; Interleukin; Tumor necrosis factor-alpha; Tumor associated macrophages; NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; ENDOTHELIAL GROWTH-FACTOR; CHEMOKINE RECEPTOR CXCR4; REGULATORY T-CELLS; INFILTRATING MACROPHAGES; SIGNALING PATHWAY; SERUM-LEVELS; PPAR-GAMMA; IN-VIVO;

D O I：

10.1016/j.cytogfr.2018.01.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pancreatic cancer is considered as one of the most lethal types of cancer due to its poor prognosis and lack of effective therapeutic approaches. Although many studies have been done on pancreatic cancer, the current treatment methods did not exhibit successful results. Hence, novel strategies are needed for treatment of pancreatic cancer. The microenvironment of pancreatic cancer contains many factors such as inflammatory cytokines and tumor associated macrophages (TAMs), which influence the tumor's status. These factors can be upregulated and consequently lead to exacerbation of tumor progression. Understanding the role of pro-and anti-inflammatory cytokines and the function of TAMs in the pancreatic cancer microenvironment might lead to development and improvement of novel strategies in the diagnosis and treatment of pancreatic cancer and may result in promising treatments for this type of cancer.

引用

页码：46 / 61

页数：16

共 242 条

[1]

ADELMAN JS, 2009, INTEGR COMP BIOL

[2] The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages [J].