Giant Suppression of Photobleaching for Single Molecule Detection via the Purcell Effect

被引:69
作者
Cang, Hu [1 ,2 ]
Liu, Yongmin [1 ,3 ,4 ]
Wang, Yuan [1 ]
Yin, Xiaobo [1 ,5 ]
Zhang, Xiang [1 ,5 ]
机构
[1] Univ Calif Berkeley, NSF Nanoscale Sci & Engn Ctr NSEC, Berkeley, CA 94720 USA
[2] Salk Inst Biol Studies, Waitt Adv Biophoton Ctr, La Jolla, CA 92037 USA
[3] Northeastern Univ, Dept Mech & Ind Engn, Boston, MA 02115 USA
[4] Northeastern Univ, Dept Elect & Comp Engn, Boston, MA 02115 USA
[5] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA
关键词
Nano-optics; single-molecule fluorescence spectroscopy; plasmonics; SPONTANEOUS EMISSION; RAMAN-SCATTERING; FLUORESCENCE; FIELD; ANTENNAS;
D O I
10.1021/nl403047m
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We report giant suppression of photobleaching and a prolonged lifespan of single fluorescent molecules via the Purcell effect in plasmonic nanostructures. The plasmonic structures enhance the spontaneous emission of excited fluorescent molecules, reduce the probability of activating photochemical reactions that destroy the molecules, and hence suppress the bleaching. Experimentally, we observe up to a 1000-fold increase in the total number of photons that we can harvest from a single fluorescent molecule before it bleaches. This approach demonstrates the potential of using the Purcell effect to manipulate photochemical reactions at the subwavelength scale.
引用
收藏
页码:5949 / 5953
页数:5
相关论文
共 43 条
[1]   Dielectric sensing in ε-near-zero narrow waveguide channels [J].
Alu, Andrea ;
Engheta, Nader .
PHYSICAL REVIEW B, 2008, 78 (04)
[2]   Enhancement and quenching of single-molecule fluorescence [J].
Anger, P ;
Bharadwaj, P ;
Novotny, L .
PHYSICAL REVIEW LETTERS, 2006, 96 (11)
[3]   Surface plasmon subwavelength optics [J].
Barnes, WL ;
Dereux, A ;
Ebbesen, TW .
NATURE, 2003, 424 (6950) :824-830
[4]  
Barnes WL, 1998, J MOD OPTIC, V45, P661, DOI 10.1080/09500349808230614
[5]   ENZYMATIC REMOVAL OF OXYGEN FOR POLAROGRAPHY AND RELATED METHODS [J].
BENESCH, RE ;
BENESCH, R .
SCIENCE, 1953, 118 (3068) :447-448
[6]   Robustness of Quantum Dot Power-Law Blinking [J].
Bharadwaj, Palash ;
Novotny, Lukas .
NANO LETTERS, 2011, 11 (05) :2137-2141
[7]   Optical Antennas [J].
Bharadwaj, Palash ;
Deutsch, Bradley ;
Novotny, Lukas .
ADVANCES IN OPTICS AND PHOTONICS, 2009, 1 (03) :438-483
[8]   Probing the structure of single-molecule surface-enhanced Raman scattering hot spots [J].
Camden, Jon P. ;
Dieringer, Jon A. ;
Wang, Yingmin ;
Masiello, David J. ;
Marks, Lawrence D. ;
Schatz, George C. ;
Van Duyne, Richard P. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (38) :12616-+
[9]   Probing the electromagnetic field of a 15-nanometre hotspot by single molecule imaging [J].
Cang, Hu ;
Labno, Anna ;
Lu, Changgui ;
Yin, Xiaobo ;
Liu, Ming ;
Gladden, Christopher ;
Liu, Yongmin ;
Zhang, Xiang .
NATURE, 2011, 469 (7330) :385-+
[10]   Multipolar radiation of quantum emitters with nanowire optical antennas [J].
Curto, Alberto G. ;
Taminiau, Tim H. ;
Volpe, Giorgio ;
Kreuzer, Mark P. ;
Quidant, Romain ;
van Hulst, Niek F. .
NATURE COMMUNICATIONS, 2013, 4