A Molecularly Imprinted Polymer for the Reconstruction of a Molecular Recognition Region

被引:16
作者
Murakami, Sachiko [1 ]
Yamamoto, Ken-ichi [1 ]
Shinmori, Hideyuki [1 ]
Takeuchi, Toshifumi [1 ]
机构
[1] Kobe Univ, Grad Sch Sci & Technol, Nada Ku, Kobe, Hyogo 6578501, Japan
关键词
D O I
10.1246/cl.2008.1028
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Cofactor-binding protein mimics were prepared by metalloporphyrin-based covalent molecular imprinting of amino acid derivatives, where an apo-type scaffold was obtained by removing the template and the porphyrin moieties from the resulting, polymer after the imprinting process, and when the porphyrin derivative was incorporated as the cofactor to yield the holo-type binding sites, enantioselectivity was induced and the chirality of the target amino acids was recognized.
引用
收藏
页码:1028 / 1029
页数:2
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