pH- and temperature-responsive poly(aspartic acid)-l-poly (N-isopropylacrylamide) conetwork hydrogel

被引：44

作者：

Nemethy, Arpad ^{[1
]}

Solti, Katalin ^{[1
]}

Kiss, Lorand ^{[3
]}

Gyarmati, Benjamin ^{[1
]}

Deli, Maria A. ^{[3
]}

Csanyi, Erzsebet ^{[2
]}

Szilagyi, Andras ^{[1
]}

机构：

[1] Budapest Univ Technol & Econ, Dept Phys Chem & Mat Sci, Soft Matters Team, H-1111 Budapest, Hungary

[2] Univ Szeged, Fac Pharm, Dept Pharmaceut Technol, H-6720 Szeged, Hungary

[3] Hungarian Acad Sci, Biol Res Ctr, Inst Biophys, H-6726 Szeged, Hungary

来源：

EUROPEAN POLYMER JOURNAL | 2013年 / 49卷 / 09期

关键词：

Multiresponsive hydrogels; Biopolymers; Poly(amino acid); Poly(N-isopropylacrylamide); Conetwork; Drug delivery systems; CONTROLLED-RELEASE; DRUG-RELEASE; POLYMERS; ACID); THERMO; ALGINATE;

D O I：

10.1016/j.eurpolymj.2013.02.015

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Multiresponsive conetwork hydrogels, PASP-l-PNIPAAm, composed of pH-responsive, biodegradable poly(aspartic acid) (PASP) and thermoresponsive poly(N-isopropylacrylamide) (PNIPAAm) were synthesized by the reaction of allylamine-grafted polysuccinimide and N-isopropylacrylamide in organic medium and a subsequent hydrolysis. The composition of allylamine-modified polymer was determined by nuclear magnetic resonance (NMR) and Fourier transformation infrared spectroscopy (FTIR). pH and temperature sensitivities were studied by measurement of swelling degrees. Scanning electron microscopic (SEM) analysis revealed that the pore size and the morphology of the PASP-l-PNIPAAm hydrogel could be controlled by the ambient pH and temperature. The volume phase transition temperature of the gels was determined by differential scanning calorimetry (DSC). A widely used non-steroidal anti-inflammatory drug, DiclofenacNa (DFS) was chosen as a model drug for drug release experiments. The hydrogel was non-toxic for human epithelial cells. According to the results these hydrogels are suitable for colon-specific controlled drug delivery. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：2392 / 2403

页数：12

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