Pomegranate Supplementation Improves Affective and Motor Behavior in Mice after Radiation Exposure

被引：26

作者：

Dulcich, Melissa S. ^{[1
]}

Hartman, Richard E. ^{[1
]}

机构：

[1] Loma Linda Univ, Behav Neurosci Lab, Dept Psychol, Sch Behav Hlth, Loma Linda, CA 92350 USA

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2013年 / 2013卷

关键词：

OXIDATIVE STRESS; JUICE CONSUMPTION; FRUIT POLYPHENOLS; EXTRACT; NEUROGENESIS; MODEL; WOMEN; SEEDS; BRAIN; STATE;

D O I：

10.1155/2013/940830

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Currently, NASA has plans for extended space travel, and previous research indicates that space radiation can have negative effects on cognitive skills as well as physical and mental health. With long-termspace travel, astronauts will be exposed to greater radiation levels. Research shows that an antioxidant-enriched diet may offer some protection against the cellular effects of radiation and may provide significant neuroprotection from the effects of radiation-induced cognitive and behavioral skill deficits. Ninety-six C57BL/6 mice (48 pomegranate fed and 48 control) were irradiated with proton radiation (2Gy), and two-month postradiation behaviors were assessed using a battery of behavioral tests to measure cognitive and motor functions. Proton irradiation was associated with depression-like behaviors in the tail suspension test, but this effect was ameliorated by the pomegranate diet. Males, in general, displayed worse coordination and balance than females on the rotarod task, and the pomegranate diet ameliorated this effect. Overall, it appears that proton irradiation, which may be encountered in space, may induce a different pattern of behavioral deficits in males than females and that a pomegranate diet may confer protection against some of those effects.

引用

页数：8

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