Cytotoxic activity screening of some indigenous Thai plants

被引：211
|
作者：
Prayong, P. [2 ]
Barusrux, S. [3 ]
Weerapreeyakul, N. [1 ]
机构：
[1] Khon Kaen Univ, Fac Pharmaceut Sci, CRD HHP, Khon Kaen 40002, Thailand
[2] Khon Kaen Univ, Grad Sch, Khon Kaen 40002, Thailand
[3] Khon Kaen Univ, Fac Associated Med Sci, Ctr Res & Dev Med Diagnost Labs, Khon Kaen 40002, Thailand
来源：
FITOTERAPIA | 2008年 / 79卷 / 7-8期
关键词：
Cytotoxic screening; HepG2; Vero; Thai plants;
D O I：
10.1016/j.fitote.2008.06.007
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The 50% ethanolic extracts from 14 plant species used in Thai traditional folklore were screened for cytotoxic activity against a malignant human hepatoma (HepG2) cell line and a normal African green monkey kidney (Vero) cell line. The extracts of Polyalthia evecta and Erythroxylum cuneatum showed potent anticancer activity in the HepG2 cell line with IC50 of 70 +/- 3 mu g/ml and 64 +/- 4 mu g/ml, respectively. P. evecta demonstrated more selectivity to the HepG2 than the Vero cell (selectivity index>14.3) indicating its potential for biopharmaceutical use. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：598 / 601
页数：4
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