Utility of quaternary ammonium salts in synthesis of some novel cyanine dyes as potential antibacterial and antitumor agents

被引：29
作者：
Fadda, A. A. [1 ]
El-Mekawy, Rasha E. [1 ]
机构：
[1] Mansoura Univ, Fac Sci, Dept Chem, Mansoura, Egypt
来源：
DYES AND PIGMENTS | 2013年 / 99卷 / 02期
关键词：
Cyclohexanone; 2-Benzylpyridine; p-nitrobenzaldehyde; 4-Hydroxy-3,4-dimethoxybenzaldehyde; 2-Mercaptothiazole; 4-((4-nitrophenyl)diazenyl)aniline; PHTHALOCYANINES; ANTIOXIDANT; PROBES;
D O I：
10.1016/j.dyepig.2013.04.037
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A novel class of quaternary ammonium salts has been synthesized in high yield by a convenient procedure which cleanly afforded a new series of methine cyanine dyes 5-11. Structural spectral studies were carried out via measuring the electronic visible absorption spectra of these dyes in DMF. Structural confirmations were determined through elemental analysis, IR, C-13 NMR, H-1 NMR spectroscopy and mass spectral data. The newly synthesized compounds were screened for their antibacterial and antitumor activity. Among all the tested compounds, it was found that compound 5 revealed better activity against Gram positive rather than Gram negative bacteria. Also, compound 5 showed better activity as antitumor agent. (C) 2013 Elsevier Ltd. All rights reserved.
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收藏
页码：512 / 519
页数：8
相关论文
共 63 条
[1]   Stereoselective Synthesis and Antiviral Activity of (1E,2Z,3E)-1-(Piperidin-1-yl)-1-(arylhydrazono)-2-[(benzoyl/benzothiazol-2-oyl)hydrazono]-4-(aryl1)but-3-enes [J].
Abdel-Aziz, Hatem A. ;
Abdel-Wahab, Bakr F. ;
Badria, Farid A. .
ARCHIV DER PHARMAZIE, 2010, 343 (03) :152-159
[2]   Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles [J].
Abdel-Wahab, Bakr F. ;
Awad, Ghada E. A. ;
Badria, Farid A. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (05) :1505-1511
[3]   DNA Binding, Antiviral Activities and Cytotoxicity of New Furochromone and Benzofuran Derivatives [J].
Abdelhafez, Omaima Mohamed ;
Abedelatif, Nehad Ahmed ;
Badria, Farid A. .
ARCHIVES OF PHARMACAL RESEARCH, 2011, 34 (10) :1623-1632
[4]   A comparative study of carbocyanine dyes measured with TOF-SIMS and other mass spectrometric techniques [J].
Adriaensen, L ;
Vangaever, F ;
Gijbels, R .
APPLIED SURFACE SCIENCE, 2004, 231 :348-352
[5]   The mechanism of benzothiazole styrylcyanine dyes binding with dsDNA: Studies by spectral-luminescent methods [J].
Akbay, N. ;
Losytskyy, M. Yu. ;
Kovalska, V. B. ;
Balanda, A. O. ;
Yarmoluk, S. M. .
JOURNAL OF FLUORESCENCE, 2008, 18 (01) :139-147
[6]   Synthesis and properties of 1,4-bis[N-(2-tolylsulphonylaminoethyl)]-1,4-diazacyclohexane bridged network polymeric phthalocyanines [J].
Akdemir, N ;
Agar, E ;
Sasmaz, S ;
Gümrükcüoglu, IE ;
Çelebi, T .
DYES AND PIGMENTS, 2006, 69 (1-2) :1-6
[7]   Synthesis, spectroscopy, electrochemistry and in situ spectroelectrochemistry of partly halogenated coumarin phthalonitrile and corresponding metal-free, cobalt and zinc phthalocyanines [J].
Alemdar, Aydin ;
Ozkaya, Ali Rlza ;
Bulut, Mustafa .
POLYHEDRON, 2009, 28 (17) :3788-3796
[8]  
Anthoni U, 1991, COMP BIOCH PHYSL, V1, P99
[9]   In vitro and in vivo study of cucurbitacins-type triterpene glucoside from Citrullus colocynthis growing in Saudi Arabia against hepatocellular carcinoma [J].
Ayyad, Seif-Eldin N. ;
Abdel-Lateff, Ahmed ;
Alarif, Walied M. ;
Patacchioli, Francesca R. ;
Badria, Farid A. ;
Ezmirly, Saleh T. .
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2012, 33 (02) :245-251
[10]   Antioxidant, cytotoxic, antitumor, and protective DNA damage metabolites from the red sea brown alga Sargassum sp [J].
Ayyad, Seif-Eldin N. ;
Ezmirly, Saleh T. ;
Basaif, Salim A. ;
Alarif, Walied M. ;
Badria, Adel F. ;
Badria, Farid A. .
PHARMACOGNOSY RESEARCH, 2011, 3 (03) :160-165
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