NEW BIODEGRADABLE BIOMEDICAL POLYMERS BASED ON SUCCINIC ACID

A short review with 41 references on new functional polyesters and poly(ester-anhydride)s based on succinic acid is presented. The properties of poly(3-allyloxy-1,2-propylene succinate) and its possible use as a component of biodegradable bone cements are discussed. The methods for the oxidation of pendant allyl groups to other functional groups, including epoxy, with formation of polyester-epoxy resins potentially used in the preparation of biodegradable bone implants, are described. The second part of the article concerns various synthetic methods available for the preparation of poly(ester-anhydride)s based on oligo(3-allyloxy-1,2-propylene succinate). In order to obtain poly(ester-anhydride)s with different properties, various aliphatic dicarboxylic acids were employed in the syntheses. Also, the possibility of using selected poly(ester-anhydride)s for the construction of microsphere polymer-drug systems is discussed. The microspheres with porous structure can be used in controlled pulmonary drug delivery.