Investigation of water-soluble inclusion complex of hypericin with β-cyclodextrin polymer

被引：69

作者：

Zhang, Wang ^{[1
]}

Gong, Xiangdong ^{[1
]}

Cai, Yin ^{[1
]}

Zhang, Chuanli ^{[2
]}

Yu, Xing ^{[2
]}

Fan, Jian ^{[2
]}

Diao, Guowang ^{[1
]}

机构：

[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China

[2] Yangzhou Univ, Coll Med, Yangzhou 225002, Jiangsu, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2013年 / 95卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Hypericin; beta-Cyclodextrin polymer; Inclusion complex; Characterization; GAMMA-CYCLODEXTRIN; BEHAVIOR; TRANSPORT; DELIVERY; BINDING; ACID;

D O I：

10.1016/j.carbpol.2013.03.020

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A water-soluble inclusion complex of hypericin (HY) with beta-cyclodextrin polymer (CDP) was achieved by supramolecular interactions between HY and CDP. The inclusion complex (HY-CDP) was characterized by H-1 NMR, FTIR, and UV-vis spectroscopies. Compared with HY, the water-solubility of HY-CDP was greatly enhanced because of the water-soluble CDP host. The mole ratio of beta-cyclodextrin (beta-CD) unit in CDP to HY was determined as 2:1. At 25 degrees C, the dissociated constant of HY-CDP was measured as 1.47 x 10(-7) mol L-1 by UV-vis spectroscopy. In the formation of inclusion complexes, CDP could overcome the beta-CD drawbacks-such as the poor water-solubility and the restriction of single cavity size, indicating it was able to use as a universal solubilizer for pharmaceutical application. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：366 / 370

页数：5

共 29 条

[1] Hypericin in cancer treatment: more light on the way
Agostinis, P
Vantieghem, A
Merlevede, W
de Witte, PAM
[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2002, 34 (03) : 221 - 241
[2] Efficacy of antitumoral photodynamic therapy with hypericin: Relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model
Chen, B
Xu, Y
Roskams, T
Delaey, E
Agostinis, P
Vandenheede, JR
de Witte, P
[J]. INTERNATIONAL JOURNAL OF CANCER, 2001, 93 (02) : 275 - 282
[3] Study of inclusion complex of β-cyclodextrin and nitrobenzene
Chen, M
Diao, GW
Zhang, ER
[J]. CHEMOSPHERE, 2006, 63 (03) : 522 - 529
[4] Development of glucose amperometric biosensor based on a novel attractive enzyme immobilization matrix: Amino derivative of thiacalix[4]arene
Chen, Ming
Zhang, Wang
Jiang, Ruimiao
Diao, Guowang
[J]. ANALYTICA CHIMICA ACTA, 2011, 687 (02) : 177 - 183
[5] Development of a simple, rapid and reproducible HPLC assay for the simultaneous determination of hypericins and stabilized hyperforin in commercial St. John's Wort preparations
de los Reyes, GC
Koda, RT
[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2001, 26 (5-6) : 959 - 965
[6] Synthesis and properties of hypericins substituted with acidic and basic residues: Hypericin tetrasulfonic acid - A water soluble hypericin derivative
Falk, H
Sarhan, AEWAO
Tran, HTN
Altmann, R
[J]. MONATSHEFTE FUR CHEMIE, 1998, 129 (03): : 309 - 318
[7] Complexation of carbendazim with hydroxypropyl-β-cyclodextrin to improve solubility and fungicidal activity
Ge, Xia
Huang, Zheng
Tian, Shilong
Huang, Yulong
Zeng, Chaozhen
[J]. CARBOHYDRATE POLYMERS, 2012, 89 (01) : 208 - 212
[8] Investigation of inclusion complex of cilnidipine with hydroxypropyl-β-cyclodextrin
Hu, Liandong
Zhang, Hailei
Song, Weihua
Gu, Deliang
Hu, Qiaofeng
[J]. CARBOHYDRATE POLYMERS, 2012, 90 (04) : 1719 - 1724
[9] Preparation of the β-cyclodextrin-vitamin C (β-CD-Vc) inclusion complex under high hydrostatic pressure (HHP)
Hu, Xiuting
Wei, Benxi
Li, Hongyan
Wu, Chunsen
Bai, Yuxiang
Xu, Xueming
Jin, Zhengyu
Tian, Yaoqi
[J]. CARBOHYDRATE POLYMERS, 2012, 90 (02) : 1193 - 1196
[10] Development of a new LDL-based transport system for hydrophobic/amphiphilic drug delivery to cancer cells
Huntosova, Veronika
Buzova, Diana
Petrovajova, Dana
Kasak, Peter
Nadova, Zuzana
Jancura, Daniel
Sureau, Franck
Miskovsky, Pavol
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2012, 436 (1-2) : 463 - 471

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