Signification of Epstein-Barr virus detection in the cerebrospinal fluid of a patient with human immunodeficiency virus related Burkitt lymphoma

被引：1
|
作者：
Jennane, Selim [1 ]
Mahtat, El Mehdi [1 ]
Konopacki, Johanna [2 ]
Foissaud, Vincent [3 ]
Souleau, Bertrand [2 ]
Malfuson, Jean Valere [2 ]
De Revel, Thierry [2 ]
机构：
[1] Hop Mil Instruct Mohammed V, Serv Hematol Clin, Rabat, Morocco
[2] Hop Instruct Armees Percy, Serv Hematol, Clamart, France
[3] Hop Instruct Armees Percy, Med Biol Lab, Clamart, France
来源：
ANNALES DE BIOLOGIE CLINIQUE | 2013年 / 71卷 / 03期
关键词：
Epstein-Barr virus; human immunodeficiency virus; Burkitt lymphoma; cerebrospinal fluid; INFECTION;
D O I：
10.1684/abc.2013.0814
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
The significance of Epstein-Barr virus detection in the cerebrospinal fluid of patients with Burkitt lymphoma is poorly studied. We report the case of a patient with immunodeficiency associated Burkitt lymphoma in complete remission who presented 5 months after the end of treatment, an isolated optic neuritis. Lumbar puncture found lymphocytic meningitis and the viral load of Epstein-Barr virus was 234,000 copies per milliliter in the cerebrospinal fluid. These symptoms could be explained by Epstein-Barr virus meningoencephalitis but the detection of MYC rearrangements in the cerebrospinal fluid confirms the diagnosis of Burkitt lymphoma cerebral relapse. The detection of the Epstein-Barr virus DNA in the cerebrospinal fluid should be interpreted with caution.
引用
收藏
页码：341 / 344
页数：4
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