Signification of Epstein-Barr virus detection in the cerebrospinal fluid of a patient with human immunodeficiency virus related Burkitt lymphoma

被引：1

作者：

Jennane, Selim ^{[1
]}

Mahtat, El Mehdi ^{[1
]}

Konopacki, Johanna ^{[2
]}

Foissaud, Vincent ^{[3
]}

Souleau, Bertrand ^{[2
]}

Malfuson, Jean Valere ^{[2
]}

De Revel, Thierry ^{[2
]}

机构：

[1] Hop Mil Instruct Mohammed V, Serv Hematol Clin, Rabat, Morocco

[2] Hop Instruct Armees Percy, Serv Hematol, Clamart, France

[3] Hop Instruct Armees Percy, Med Biol Lab, Clamart, France

来源：

ANNALES DE BIOLOGIE CLINIQUE | 2013年 / 71卷 / 03期

关键词：

Epstein-Barr virus; human immunodeficiency virus; Burkitt lymphoma; cerebrospinal fluid; INFECTION;

D O I：

10.1684/abc.2013.0814

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The significance of Epstein-Barr virus detection in the cerebrospinal fluid of patients with Burkitt lymphoma is poorly studied. We report the case of a patient with immunodeficiency associated Burkitt lymphoma in complete remission who presented 5 months after the end of treatment, an isolated optic neuritis. Lumbar puncture found lymphocytic meningitis and the viral load of Epstein-Barr virus was 234,000 copies per milliliter in the cerebrospinal fluid. These symptoms could be explained by Epstein-Barr virus meningoencephalitis but the detection of MYC rearrangements in the cerebrospinal fluid confirms the diagnosis of Burkitt lymphoma cerebral relapse. The detection of the Epstein-Barr virus DNA in the cerebrospinal fluid should be interpreted with caution.

引用

页码：341 / 344

页数：4

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