Rattle-type Au@Cu2-xS hollow mesoporous nanocrystals with enhanced photothermal efficiency for intracellular oncogenic microRNA detection and chemo-photothermal therapy

被引：76

作者：

Cao, Yu ^{[1
]}

Li, Shuzhou ^{[2
]}

Chen, Chao ^{[2
]}

Wang, Dongdong ^{[1
]}

Wu, Tingting ^{[1
]}

Dong, Haifeng ^{[1
]}

Zhang, Xueji ^{[1
]}

机构：

[1] Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing Key Lab Bioengn & Sensing Technol, Res Ctr Bioengn & Sensing Technol, Beijing 100083, Peoples R China

[2] Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore

来源：

BIOMATERIALS | 2018年 / 158卷

基金：

中国国家自然科学基金;

关键词：

Rattle-type Au@Cu2-xS; Localized surface plasma resonance; coupling; Chemo-photothermal therapy; MicroRNA detection; Theranostic platform; GOLD NANOPARTICLES; ABLATION; AGENT; SHELL; NANOSTRUCTURES;

D O I：

10.1016/j.biomaterials.2017.12.009

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The coupling of the localized surface plasma resonance (LSPR) between noble metals of Au, Ag and Cu and semiconductors of Cu2-xE (E = S, Se, Te) opens new regime to design photothermal (PT) agents with enhanced PT conversion efficiency. However, it is rarely explored on fabricating of engineered dual plasmonic hybrid nanosystem for combinatory therapeutic-diagnostic applications. Herein, rattle-type Au@Cu2-xS hollow mesoporous nanoparitcles with advanced PT conversion efficiency are designed for cellular vehicles and chemo-photothermal synergistic therapy platform. The LSPR coupling between the Au core and Cu2-xS shell are investigated experimentally and theoretically to generate a PT conversion efficiency high to 35.2% and enhanced by 11.3% than that of Cu2-xS. By conjugating microRNA (miRNA) gene probe on the surface, it can realize the intracellular oncogenic miRNA detection. After loading of anticancer drug doxorubicin into the cavity of the Au@Cu2-xS, the antitumor therapy efficacy is greatly enhanced in vitro and in vivo due to the NIR photoactivation chemo- and photothermal synergistic therapy. The rattle-type metal-semiconductor hollow mesoporous nanostructure with efficient LSPR coupling and high cargo loading capability will be beneficial to future design of LSPR-based photo thermal agents for a broad range of biomedical application. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：23 / 33

页数：11

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