Emerging Strategies of Nanomaterial-Mediated Tumor Radiosensitization

被引:337
作者
Xie, Jiani [1 ]
Gong, Linji [1 ]
Zhu, Shuang [1 ]
Yong, Yuan [1 ]
Gu, Zhanjun [1 ,2 ]
Zhao, Yuliang [1 ,2 ,3 ]
机构
[1] Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China
[2] Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China
[3] Chinese Acad Sci, CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China
基金
中国国家自然科学基金;
关键词
clinical translation; nanomaterial-mediated radiosensitization; nanoradiosensitizers; radioprotection; synergistic radiotherapy; GADOLINIUM-BASED NANOPARTICLES; CONJUGATED GOLD NANOPARTICLES; ENHANCED PHOTODYNAMIC THERAPY; IONIZING-RADIATION LETHALITY; UP-CONVERSION NANOPARTICLES; INDEPENDENT PROSTATE-CANCER; IMAGING-GUIDED RADIOTHERAPY; PEP-PCL NANOPARTICLES; HEPATOMA HEPG2 CELLS; IN-VIVO;
D O I
10.1002/adma.201802244
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nano-radiosensitization has been a hot concept for the past ten years, and the nanomaterial-mediated tumor radiosensitization method is mainly focused on increasing intracellular radiation deposition by high atomic number (high Z) nanomaterials, particularly gold (Au)-mediated radiation enhancement. Recently, various new nanomaterial-mediated radiosensitive approaches have been successively reported, such as catalyzing reactive oxygen species (ROS) generation, consuming intracellular reduced glutathione (GSH), overcoming tumor hypoxia, and various synergistic radiotherapy ways. These strategies may open a new avenue for enhancing the radiotherapeutic effect and avoiding its side effects. Nevertheless, reviews systematically summarizing these newly emerging methods and their radiosensitive mechanisms are still rare. Therefore, the general strategies of nanomaterial-mediated tumor radiosensitization are comprehensively summarized, particularly aiming at introducing the emerging radiosensitive methods. The strategies are divided into three general parts. First, methods on account of the intrinsic radiosensitive properties of nanoradiosensitizers for radiosensitization are highlighted. Then, newly developed synergistic strategies based on multifunctional nanomaterials for enhancing radiotherapy efficacy are emphasized. Third, nanomaterial-mediated radioprotection approaches for increasing the radiotherapeutic ratio are discussed. Importantly, the clinical translation of nanomaterial-mediated tumor radiosensitization is also covered. Finally, further challenges and outlooks in this field are discussed.
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页数:25
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